Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2508161..2508678 Replicon chromosome
Accession NZ_CP038612
Organism Staphylococcus aureus strain O268

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SaO268_RS13140 Protein ID WP_000375483.1
Coordinates 2508161..2508427 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SaO268_RS13145 Protein ID WP_000584499.1
Coordinates 2508427..2508678 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO268_RS13115 2503312..2503848 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SaO268_RS13120 2504368..2505192 - 825 WP_000594631.1 formate/nitrite transporter family protein -
SaO268_RS13125 2505395..2505577 - 183 WP_000079140.1 hypothetical protein -
SaO268_RS13130 2505664..2506131 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SaO268_RS13135 2506317..2507867 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SaO268_RS13140 2508161..2508427 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
SaO268_RS13145 2508427..2508678 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO268_RS13150 2508842..2508942 - 101 Protein_2450 hypothetical protein -
SaO268_RS13155 2508949..2509548 - 600 WP_000162810.1 DsbA family protein -
SaO268_RS13160 2509567..2509929 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SaO268_RS13165 2510184..2511434 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
SaO268_RS13170 2511527..2512258 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SaO268_RS13175 2512255..2512974 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T123072 WP_000375483.1 NZ_CP038612:c2508427-2508161 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T123072 NZ_CP038612:c2508427-2508161 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT123072 WP_000584499.1 NZ_CP038612:c2508678-2508427 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT123072 NZ_CP038612:c2508678-2508427 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References