Detailed information of TA system TA123064

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1144265..1144577
• Replicon: chromosome
• Accession: NZ_CP038612
• Organism: Staphylococcus aureus strain O268

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SaO268_RS05935
• Protein ID: WP_078061146.1
• Coordinates: 1144265..1144441 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1144498..1144577 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO268_RS05910	1141881..1142033	+	153	WP_001153680.1	hypothetical protein	-
SaO268_RS05915	1142080..1142367	+	288	WP_001040261.1	hypothetical protein	-
SaO268_RS05920	1142462..1142830	+	369	WP_135831022.1	hypothetical protein	-
SaO268_RS05930	1143285..1144064	+	780	WP_000746437.1	exotoxin	-
SaO268_RS05935	1144265..1144441	+	177	WP_078061146.1	putative holin-like toxin	Toxin
-	1144498..1144577	-	80	-	-	Antitoxin
SaO268_RS05945	1144644..1145081	+	438	WP_000354125.1	phage holin	-
SaO268_RS05950	1145062..1145670	+	609	Protein_1121	CHAP domain-containing protein	-
SaO268_RS05955	1145733..1146278	+	546	WP_000136401.1	NUMOD4 motif-containing HNH endonuclease	-
SaO268_RS05960	1146602..1147441	+	840	Protein_1123	SH3 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea	1108119..1147441	39322

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6848.50 Da
• Isoelectric Point: 10.6777

>T123064 WP_078061146.1 NZ_CP038612:1144265-1144441 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Nucleotide

• Length: 177 bp

>T123064 NZ_CP038612:1144265-1144441 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCGCTAATTGGTCTAGTAATCAAGCTTATTGAAT
TAAGCATTAAAAAATAA

Antitoxin

Nucleotide

• Length: 80 bp

>AT123064 NZ_CP038612:c1144577-1144498 [Staphylococcus aureus]
GATGTGTTAATTTATATATAGAAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACTA

Structures

Antitoxin