Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 454026..454732 Replicon chromosome
Accession NZ_CP038498
Organism Pectobacterium punjabense strain SS95

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E2566_RS02100 Protein ID WP_107169476.1
Coordinates 454026..454319 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E2566_RS02105 Protein ID WP_107169427.1
Coordinates 454316..454732 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2566_RS02080 449078..449995 + 918 WP_107170956.1 type I-E CRISPR-associated endonuclease Cas1 -
E2566_RS02085 449996..450289 + 294 WP_005973730.1 type I-E CRISPR-associated endoribonuclease Cas2 -
E2566_RS02090 453167..453538 - 372 WP_012822192.1 helix-turn-helix domain-containing protein -
E2566_RS02095 453612..453872 - 261 WP_107169426.1 type II toxin-antitoxin system RelE/ParE family toxin -
E2566_RS02100 454026..454319 + 294 WP_107169476.1 type II toxin-antitoxin system HigB family toxin Toxin
E2566_RS02105 454316..454732 + 417 WP_107169427.1 helix-turn-helix domain-containing protein Antitoxin
E2566_RS02110 454936..455439 - 504 WP_107169428.1 hypothetical protein -
E2566_RS02115 457970..458428 + 459 WP_107169429.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(27-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11694.54 Da        Isoelectric Point: 9.7151

>T122988 WP_107169476.1 NZ_CP038498:454026-454319 [Pectobacterium punjabense]
VFPRTPFDTAIAQLLNPATALADLYRVIYATPDDMKKRFPSLDRIKFREKWWVIDIGGGHLRVMFFADFEREKIFIKHIT
THAEYDRLIEYYRRNKE

Download         Length: 294 bp

>T122988 NZ_CP038498:454026-454319 [Pectobacterium punjabense]
GTGTTCCCCCGGACACCTTTTGACACTGCAATCGCCCAGCTCCTGAATCCGGCGACAGCACTGGCTGACTTATATCGGGT
TATCTATGCAACGCCGGACGATATGAAAAAACGCTTCCCCAGCTTAGACAGGATAAAGTTCAGGGAAAAGTGGTGGGTGA
TTGATATCGGTGGTGGGCATCTTCGCGTGATGTTTTTTGCAGATTTTGAGCGAGAGAAGATCTTCATTAAACACATTACC
ACCCATGCAGAGTATGACAGGCTGATAGAGTATTACCGGAGGAATAAAGAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15380.64 Da        Isoelectric Point: 4.4838

>AT122988 WP_107169427.1 NZ_CP038498:454316-454732 [Pectobacterium punjabense]
MMYADAIKAANTLTSIVPFLGGSTSRKDYEDALKLTEYLIESEPDSPLIDMLTAKIDKYEEDAPEFADFNERIKALPAGI
ALLRILMDQHGLTQSDFEAEIGKKSLVSRILNGERTLTLDHMKALAKRFDIPVSAFID

Download         Length: 417 bp

>AT122988 NZ_CP038498:454316-454732 [Pectobacterium punjabense]
ATGATGTACGCAGACGCTATCAAGGCCGCTAACACGCTGACGAGTATCGTACCGTTCCTCGGAGGTAGCACCTCTCGTAA
AGATTATGAGGACGCGCTGAAACTCACGGAATATTTGATCGAGAGTGAGCCTGATAGCCCGCTGATCGATATGCTGACGG
CTAAAATTGATAAATATGAAGAGGATGCGCCAGAATTTGCAGACTTCAACGAGCGGATTAAAGCGCTCCCTGCGGGTATC
GCTTTACTGCGCATACTTATGGATCAGCATGGGCTAACGCAAAGTGACTTTGAAGCTGAGATCGGTAAAAAGTCTCTGGT
ATCCCGCATTTTAAACGGTGAACGTACGTTAACGCTTGATCACATGAAAGCGCTTGCTAAACGATTCGATATTCCCGTGA
GTGCTTTTATTGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References