Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4528324..4528976 Replicon chromosome
Accession NZ_CP038467
Organism Serratia quinivorans strain PKL:12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4343_RS21235 Protein ID WP_115183925.1
Coordinates 4528632..4528976 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4343_RS21230 Protein ID WP_115183924.1
Coordinates 4528324..4528626 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4343_RS21210 4523604..4524512 + 909 WP_012146542.1 LysR family transcriptional regulator -
E4343_RS21215 4524828..4525982 + 1155 WP_115183921.1 MFS transporter -
E4343_RS21220 4525972..4526895 - 924 WP_115183922.1 LysR family transcriptional regulator -
E4343_RS21225 4527028..4528290 + 1263 WP_115183923.1 diaminopimelate decarboxylase -
E4343_RS21230 4528324..4528626 - 303 WP_115183924.1 helix-turn-helix transcriptional regulator Antitoxin
E4343_RS21235 4528632..4528976 - 345 WP_115183925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4343_RS21240 4529116..4530126 - 1011 WP_115183926.1 LacI family DNA-binding transcriptional regulator -
E4343_RS21245 4530281..4530736 + 456 WP_115183927.1 GNAT family N-acetyltransferase -
E4343_RS21250 4530733..4531752 - 1020 WP_012146535.1 HTH-type transcriptional regulator GalR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13473.51 Da        Isoelectric Point: 10.2782

>T122892 WP_115183925.1 NZ_CP038467:c4528976-4528632 [Serratia quinivorans]
MWQVVTVERFDSWFLSLHSDEQKSLLVGIFKLQEFGPLLARPHADTLHHNGQIQHLKELRIQHRGRPYRVFFAFDPQRQA
VLLCGGDKTGNKRFYQQMLPIAVREFSHYLATQR

Download         Length: 345 bp

>T122892 NZ_CP038467:c4528976-4528632 [Serratia quinivorans]
ATGTGGCAGGTCGTGACCGTCGAACGATTCGACAGCTGGTTTTTATCATTACACAGCGATGAACAAAAAAGCCTGTTGGT
GGGCATCTTTAAACTGCAGGAATTTGGCCCCTTGCTGGCGCGTCCCCATGCCGACACGCTGCATCACAACGGTCAAATAC
AGCATCTGAAAGAATTACGCATTCAGCATCGTGGTCGTCCGTATCGGGTTTTCTTCGCCTTCGACCCACAACGGCAAGCG
GTTCTACTGTGCGGCGGCGACAAAACCGGCAATAAACGTTTCTATCAACAAATGCTACCGATTGCCGTCAGAGAGTTTTC
ACATTATTTGGCAACCCAGAGGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11139.05 Da        Isoelectric Point: 10.3969

>AT122892 WP_115183924.1 NZ_CP038467:c4528626-4528324 [Serratia quinivorans]
MAKPLSNLIDKLDPAVVDAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVRLPNGQHRRMSL

Download         Length: 303 bp

>AT122892 NZ_CP038467:c4528626-4528324 [Serratia quinivorans]
ATGGCCAAGCCATTATCAAATCTGATCGATAAGCTCGATCCCGCCGTGGTTGACGCGGCCCGGCAAAAAGCGGACAAAGA
AATTTTTGAACTGCGGCTGGCTATGCTGCGGGAAGAACTGGCGGTTTCCCAGGTAGAACTGGCGAAGCGGCTTGGCATCA
GCCAACCTTCTGTGGCCAATTTGGAAAAACGCGGTAGCGAAATCAAACTCTCTTCGTTAAAACGCTATATTGAAGCCATG
GGCGGTACGCTGTCGCTGGAAGTCCGACTCCCCAACGGCCAGCACCGGCGAATGTCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References