Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2916889..2917542 Replicon chromosome
Accession NZ_CP038467
Organism Serratia quinivorans strain PKL:12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4343_RS13720 Protein ID WP_085119570.1
Coordinates 2917192..2917542 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4343_RS13715 Protein ID WP_085119571.1
Coordinates 2916889..2917188 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4343_RS13690 2911944..2913125 - 1182 WP_115183347.1 acetyl-CoA C-acetyltransferase -
E4343_RS13695 2913149..2913802 - 654 WP_135344701.1 CoA transferase subunit B -
E4343_RS13700 2913813..2914511 - 699 WP_012005045.1 CoA transferase subunit A -
E4343_RS13705 2914681..2915589 + 909 WP_135344702.1 LysR family transcriptional regulator -
E4343_RS13710 2915775..2916851 + 1077 WP_012005041.1 YncE family protein -
E4343_RS13715 2916889..2917188 - 300 WP_085119571.1 helix-turn-helix transcriptional regulator Antitoxin
E4343_RS13720 2917192..2917542 - 351 WP_085119570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4343_RS13725 2917644..2917958 - 315 WP_115183349.1 hypothetical protein -
E4343_RS13730 2918153..2919526 + 1374 WP_115183350.1 glutamine synthetase family protein -
E4343_RS13735 2919590..2920300 + 711 WP_115183351.1 trehalose-6-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13490.55 Da        Isoelectric Point: 9.1015

>T122888 WP_085119570.1 NZ_CP038467:c2917542-2917192 [Serratia quinivorans]
MWTVITTEEFDRWFASQDEPTQEKVLAAMVMLGRTGPNLSRPFVDSLRGSQHPNMKELRIQHKGRPIRAFFAFDPKRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMFNFEE

Download         Length: 351 bp

>T122888 NZ_CP038467:c2917542-2917192 [Serratia quinivorans]
ATGTGGACTGTAATAACTACGGAAGAGTTTGATCGATGGTTTGCATCGCAAGATGAACCTACTCAAGAGAAGGTGCTTGC
TGCAATGGTAATGCTTGGGCGAACAGGCCCCAACCTGTCAAGGCCGTTTGTAGACTCATTGAGGGGATCACAACACCCAA
ATATGAAAGAGTTGCGAATTCAGCATAAGGGGCGGCCAATTCGTGCTTTTTTTGCATTTGATCCGAAACGTCAGGCAATC
GTTCTGTGTGCTGGCGATAAGACAGGTAACGAGAAGCGGTTTTATAAAGTCATGCTACCTATTGCAGATGCGCAATTTAC
CCAGCATTTGATGTTCAATTTTGAGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11100.80 Da        Isoelectric Point: 5.2099

>AT122888 WP_085119571.1 NZ_CP038467:c2917188-2916889 [Serratia quinivorans]
MGTLKEMLASRTPESRQRIEEMAEEMLLETRLYELREALNISQQALANSLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDIELPDGKHVGFKV

Download         Length: 300 bp

>AT122888 NZ_CP038467:c2917188-2916889 [Serratia quinivorans]
ATGGGTACTTTAAAAGAAATGTTGGCTTCACGTACTCCTGAGAGCAGGCAGCGGATCGAGGAAATGGCAGAGGAGATGCT
GTTGGAAACCCGTTTGTACGAGTTGCGCGAAGCCCTAAATATCTCGCAGCAGGCGTTGGCGAATAGTCTTGGTATTTCCC
AGCCCTCCGTTGCGGCGATCGAGCAGCGCGGGAATGAGCTAAAAATTTCGACATTAAAGCGTTATGTCGAAGCCATGGGG
GGGACACTGCGGTTGGATATCGAATTGCCGGACGGCAAGCACGTCGGGTTTAAGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References