Detailed information of TA system TA122884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1490462..1491069
• Replicon: chromosome
• Accession: NZ_CP038467
• Organism: Serratia quinivorans strain PKL:12

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A379YDW7
• Locus tag: E4343_RS06910
• Protein ID: WP_012006276.1
• Coordinates: 1490758..1491069 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E4343_RS06905
• Protein ID: WP_012006277.1
• Coordinates: 1490462..1490755 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4343_RS06875	1486129..1487430	-	1302	WP_115182727.1	6-phospho-beta-glucosidase	-
E4343_RS06880	1487423..1487749	-	327	WP_012006281.1	PTS lactose/cellobiose transporter subunit IIA	-
E4343_RS06885	1487861..1488166	-	306	WP_012006280.1	PTS sugar transporter subunit IIB	-
E4343_RS06890	1488570..1489712	+	1143	WP_115182728.1	MurR/RpiR family transcriptional regulator	-
E4343_RS06895	1489929..1490159	+	231	WP_012006278.1	hypothetical protein	-
E4343_RS06905	1490462..1490755	-	294	WP_012006277.1	helix-turn-helix domain-containing protein	Antitoxin
E4343_RS06910	1490758..1491069	-	312	WP_012006276.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4343_RS06915	1491130..1491318	+	189	WP_115182729.1	hypothetical protein	-
E4343_RS06935	1491729..1492277	-	549	WP_115182791.1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	-
E4343_RS06940	1492336..1494168	-	1833	WP_026142303.1	excinuclease ABC subunit UvrC	-
E4343_RS06945	1494161..1494817	-	657	WP_012006273.1	UvrY/SirA/GacA family response regulator transcription factor	-
E4343_RS06950	1495582..1495806	+	225	WP_012006272.1	DUF2594 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-101)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-87)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11874.67 Da
• Isoelectric Point: 9.3249

>T122884 WP_012006276.1 NZ_CP038467:c1491069-1490758 [Serratia quinivorans]
MIFIETPIFTEDVLTLLSDEEYREFQLHLAENPTAGDVIKETGGLRKVRWASGGKGKRGGVRVIYYYKLSESQIRLLVIY
KKGIKDDLSADEKRALRALNERW

Nucleotide

• Length: 312 bp

>T122884 NZ_CP038467:c1491069-1490758 [Serratia quinivorans]
ATGATATTTATAGAAACCCCGATTTTTACAGAGGATGTTCTGACGCTACTCAGTGATGAAGAGTATCGAGAGTTTCAGCT
TCATCTTGCCGAGAACCCAACCGCAGGTGATGTGATCAAAGAAACCGGCGGATTACGCAAGGTTCGTTGGGCTAGCGGCG
GCAAAGGGAAGCGTGGCGGTGTGCGGGTCATTTATTATTATAAGTTGTCCGAATCTCAGATCCGCCTGTTGGTGATCTAC
AAAAAGGGCATTAAAGATGATTTGTCTGCGGATGAAAAACGCGCCCTTCGCGCATTGAATGAGAGGTGGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10824.53 Da
• Isoelectric Point: 10.4747

>AT122884 WP_012006277.1 NZ_CP038467:c1490755-1490462 [Serratia quinivorans]
MDVKLFDRLKESMTQMNEIIDGERVPSREFNVSAVQVKNIRQATGLSQPVFAALISVSVGTLKNWEQGRREPTGPAKALL
RAIERDPQHVLPALSIK

Nucleotide

• Length: 294 bp

>AT122884 NZ_CP038467:c1490755-1490462 [Serratia quinivorans]
ATGGACGTTAAACTGTTCGATCGCTTGAAAGAAAGCATGACGCAAATGAATGAAATCATTGATGGGGAGCGCGTGCCGTC
CCGTGAATTTAATGTCAGCGCCGTCCAAGTAAAAAATATCCGCCAGGCTACCGGTTTATCCCAGCCTGTTTTTGCCGCGC
TGATTTCTGTCAGCGTGGGTACGCTTAAAAATTGGGAGCAGGGCAGACGGGAACCTACCGGCCCGGCCAAAGCGTTGCTG
CGTGCGATTGAGCGAGATCCCCAGCATGTCCTGCCTGCGCTTTCTATTAAGTGA

Structures

Toxin

• AlphaFold DB: A0A379YDW7