Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2485164..2485687 Replicon chromosome
Accession NZ_CP038461
Organism Staphylococcus aureus strain O217

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag SaO217_RS12185 Protein ID WP_000074047.1
Coordinates 2485164..2485430 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag SaO217_RS12190 Protein ID WP_000587617.1
Coordinates 2485430..2485687 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO217_RS12165 2480374..2481561 - 1188 WP_000026190.1 MFS transporter -
SaO217_RS12170 2481955..2482731 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
SaO217_RS12175 2482724..2483386 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
SaO217_RS12180 2483732..2484808 - 1077 WP_001076679.1 M42 family metallopeptidase -
SaO217_RS12185 2485164..2485430 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
SaO217_RS12190 2485430..2485687 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO217_RS12195 2486047..2486502 + 456 WP_000732090.1 YehR family lipoprotein -
SaO217_RS12200 2486670..2488247 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
SaO217_RS12205 2488443..2489192 + 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
SaO217_RS12210 2489416..2490609 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T122872 WP_000074047.1 NZ_CP038461:c2485430-2485164 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T122872 NZ_CP038461:c2485430-2485164 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT122872 WP_000587617.1 NZ_CP038461:c2485687-2485430 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT122872 NZ_CP038461:c2485687-2485430 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References