Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2453849..2454033 Replicon chromosome
Accession NZ_CP038461
Organism Staphylococcus aureus strain O217

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SaO217_RS12045 Protein ID WP_000482647.1
Coordinates 2453926..2454033 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2453849..2453909 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO217_RS12030 2449359..2449526 - 168 Protein_2329 hypothetical protein -
SaO217_RS12035 2449757..2451490 - 1734 WP_199878592.1 ABC transporter ATP-binding protein/permease -
SaO217_RS12040 2451515..2453278 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2453849..2453909 + 61 - - Antitoxin
SaO217_RS12045 2453926..2454033 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SaO217_RS12050 2454167..2454553 - 387 WP_000779351.1 flippase GtxA -
SaO217_RS12055 2454821..2455963 + 1143 WP_001176855.1 glycerate kinase -
SaO217_RS12060 2456023..2456682 + 660 WP_000831298.1 membrane protein -
SaO217_RS12065 2456864..2458075 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
SaO217_RS12070 2458198..2458671 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T122870 WP_000482647.1 NZ_CP038461:c2454033-2453926 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T122870 NZ_CP038461:c2454033-2453926 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT122870 NZ_CP038461:2453849-2453909 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References