Detailed information of TA system TA122862

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1857665..1857845
• Replicon: chromosome
• Accession: NZ_CP038461
• Organism: Staphylococcus aureus strain O217

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SaO217_RS08845
• Protein ID: WP_001801861.1
• Coordinates: 1857665..1857760 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1857788..1857845 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO217_RS08815	1852812..1853438	+	627	WP_000669038.1	hypothetical protein	-
SaO217_RS08820	1853479..1853823	+	345	WP_000627550.1	DUF3969 family protein	-
SaO217_RS08825	1853921..1854493	+	573	WP_000414222.1	hypothetical protein	-
SaO217_RS08830	1854642..1856009	-	1368	WP_001093574.1	FRG domain-containing protein	-
SaO217_RS08835	1856009..1856575	-	567	WP_103148290.1	ImmA/IrrE family metallo-endopeptidase	-
SaO217_RS08840	1856768..1857214	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
SaO217_RS08845	1857665..1857760	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1857788..1857845	-	58	-	-	Antitoxin
SaO217_RS08850	1857883..1857984	+	102	WP_001791232.1	hypothetical protein	-
SaO217_RS08855	1858159..1858602	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
SaO217_RS08860	1858602..1859045	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
SaO217_RS08865	1859045..1859487	-	443	Protein_1743	DUF1433 domain-containing protein	-
SaO217_RS08870	1860012..1862432	+	2421	WP_199878546.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / selk	1851046..1890273	39227

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T122862 WP_001801861.1 NZ_CP038461:1857665-1857760 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T122862 NZ_CP038461:1857665-1857760 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT122862 NZ_CP038461:c1857845-1857788 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin