Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2491684..2492207 Replicon chromosome
Accession NZ_CP038460
Organism Staphylococcus aureus strain B119

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SaO322_RS12910 Protein ID WP_000074048.1
Coordinates 2491684..2491950 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag SaO322_RS12915 Protein ID WP_000587617.1
Coordinates 2491950..2492207 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO322_RS12890 2486894..2488081 - 1188 WP_000026189.1 MFS transporter -
SaO322_RS12895 2488476..2489252 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
SaO322_RS12900 2489245..2489907 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
SaO322_RS12905 2490252..2491328 - 1077 WP_001076674.1 M42 family metallopeptidase -
SaO322_RS12910 2491684..2491950 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SaO322_RS12915 2491950..2492207 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO322_RS12925 2492568..2493023 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SaO322_RS12930 2493191..2494768 - 1578 WP_065315873.1 FMN-binding glutamate synthase family protein -
SaO322_RS12935 2494962..2495711 + 750 WP_000072455.1 CPBP family intramembrane metalloprotease -
SaO322_RS12940 2495935..2497128 - 1194 WP_000675398.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T122856 WP_000074048.1 NZ_CP038460:c2491950-2491684 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T122856 NZ_CP038460:c2491950-2491684 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT122856 WP_000587617.1 NZ_CP038460:c2492207-2491950 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT122856 NZ_CP038460:c2492207-2491950 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References