Detailed information of TA system TA122854

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2460365..2460549
• Replicon: chromosome
• Accession: NZ_CP038460
• Organism: Staphylococcus aureus strain B119

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: SaO322_RS12755
• Protein ID: WP_000482647.1
• Coordinates: 2460442..2460549 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2460365..2460425 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO322_RS12730	2455820..2455987	-	168	WP_041204334.1	hypothetical protein	-
SaO322_RS12740	2456218..2457951	-	1734	WP_000486497.1	ABC transporter ATP-binding protein/permease	-
SaO322_RS12745	2457976..2459739	-	1764	WP_001064817.1	ABC transporter ATP-binding protein/permease	-
-	2460365..2460425	+	61	-	-	Antitoxin
SaO322_RS12755	2460442..2460549	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
SaO322_RS12760	2460683..2461069	-	387	WP_000779350.1	flippase GtxA	-
SaO322_RS12765	2461337..2462479	+	1143	WP_118848162.1	glycerate kinase	-
SaO322_RS12770	2462539..2463198	+	660	WP_000831299.1	hypothetical protein	-
SaO322_RS12775	2463383..2464594	+	1212	WP_001191928.1	multidrug effflux MFS transporter	-
SaO322_RS12780	2464717..2465190	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T122854 WP_000482647.1 NZ_CP038460:c2460549-2460442 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T122854 NZ_CP038460:c2460549-2460442 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT122854 NZ_CP038460:2460365-2460425 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin