Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2434655..2435172 Replicon chromosome
Accession NZ_CP038460
Organism Staphylococcus aureus strain B119

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SaO322_RS12610 Protein ID WP_000375483.1
Coordinates 2434655..2434921 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SaO322_RS12615 Protein ID WP_000584499.1
Coordinates 2434921..2435172 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO322_RS12585 2429806..2430342 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SaO322_RS12590 2430862..2431686 - 825 WP_000594631.1 formate/nitrite transporter family protein -
SaO322_RS12595 2431889..2432071 - 183 WP_000079140.1 hypothetical protein -
SaO322_RS12600 2432158..2432625 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SaO322_RS12605 2432811..2434361 - 1551 WP_118848158.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SaO322_RS12610 2434655..2434921 - 267 WP_000375483.1 Txe/YoeB family addiction module toxin Toxin
SaO322_RS12615 2434921..2435172 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO322_RS12620 2435336..2435436 - 101 Protein_2339 hypothetical protein -
SaO322_RS12625 2435443..2436042 - 600 WP_000162810.1 DsbA family protein -
SaO322_RS12630 2436061..2436423 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SaO322_RS12635 2436678..2437928 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
SaO322_RS12640 2438021..2438752 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SaO322_RS12645 2438749..2439468 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10450.05 Da        Isoelectric Point: 10.2538

>T122853 WP_000375483.1 NZ_CP038460:c2434921-2434655 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T122853 NZ_CP038460:c2434921-2434655 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT122853 WP_000584499.1 NZ_CP038460:c2435172-2434921 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT122853 NZ_CP038460:c2435172-2434921 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References