Detailed information of TA system TA122853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2434655..2435172
• Replicon: chromosome
• Accession: NZ_CP038460
• Organism: Staphylococcus aureus strain B119

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SaO322_RS12610
• Protein ID: WP_000375483.1
• Coordinates: 2434655..2434921 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: SaO322_RS12615
• Protein ID: WP_000584499.1
• Coordinates: 2434921..2435172 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO322_RS12585	2429806..2430342	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
SaO322_RS12590	2430862..2431686	-	825	WP_000594631.1	formate/nitrite transporter family protein	-
SaO322_RS12595	2431889..2432071	-	183	WP_000079140.1	hypothetical protein	-
SaO322_RS12600	2432158..2432625	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
SaO322_RS12605	2432811..2434361	-	1551	WP_118848158.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
SaO322_RS12610	2434655..2434921	-	267	WP_000375483.1	Txe/YoeB family addiction module toxin	Toxin
SaO322_RS12615	2434921..2435172	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SaO322_RS12620	2435336..2435436	-	101	Protein_2339	hypothetical protein	-
SaO322_RS12625	2435443..2436042	-	600	WP_000162810.1	DsbA family protein	-
SaO322_RS12630	2436061..2436423	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
SaO322_RS12635	2436678..2437928	+	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
SaO322_RS12640	2438021..2438752	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
SaO322_RS12645	2438749..2439468	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10450.05 Da
• Isoelectric Point: 10.2538

>T122853 WP_000375483.1 NZ_CP038460:c2434921-2434655 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T122853 NZ_CP038460:c2434921-2434655 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT122853 WP_000584499.1 NZ_CP038460:c2435172-2434921 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT122853 NZ_CP038460:c2435172-2434921 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: T1YB60