Detailed information of TA system TA122842

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF3/-
• Location: 353324..353842
• Replicon: chromosome
• Accession: NZ_CP038460
• Organism: Staphylococcus aureus strain B119

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: SaO322_RS01725
• Protein ID: WP_000448764.1
• Coordinates: 353540..353842 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	353324..353460 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO322_RS01685	348418..348708	+	291	WP_000179860.1	hypothetical protein	-
SaO322_RS01690	348724..350634	+	1911	WP_000429563.1	hypothetical protein	-
SaO322_RS01695	350634..352100	+	1467	WP_000067157.1	BppU family phage baseplate upper protein	-
SaO322_RS01700	352100..352489	+	390	WP_001166604.1	DUF2977 domain-containing protein	-
SaO322_RS01705	352482..352646	+	165	WP_000916020.1	XkdX family protein	-
SaO322_RS01710	352692..352991	+	300	WP_000466773.1	DUF2951 family protein	-
SaO322_RS14300	353143..353332	+	190	Protein_326	putative holin-like toxin	-
-	353324..353460	-	137	NuclAT_0	-	Antitoxin
-	353324..353460	-	137	NuclAT_0	-	Antitoxin
-	353324..353460	-	137	NuclAT_0	-	Antitoxin
-	353324..353460	-	137	NuclAT_0	-	Antitoxin
SaO322_RS01720	353379..353489	-	111	WP_070003492.1	hypothetical protein	-
SaO322_RS01725	353540..353842	+	303	WP_000448764.1	phage holin	Toxin
SaO322_RS01730	353854..355308	+	1455	WP_000930278.1	N-acetylmuramoyl-L-alanine amidase	-
SaO322_RS01740	356822..357319	+	498	WP_001803960.1	hypothetical protein	-
SaO322_RS01750	357879..358706	-	828	WP_000136028.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	318779..355308	36529

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11230.99 Da
• Isoelectric Point: 9.6587

>T122842 WP_000448764.1 NZ_CP038460:353540-353842 [Staphylococcus aureus]
METKVITRYIVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTAYKDNPTSQEGRWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T122842 NZ_CP038460:353540-353842 [Staphylococcus aureus]
ATGGAAACAAAAGTAATAACAAGATATATTGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAACAAAGGTATAAG
CCCGATACCAGTAGATGAAGAGAGTATTTCATCGATTATCTTAACAGTCATTGCTTTATACACCGCTTATAAAGACAATC
CAACATCACAAGAAGGACGCTGGGCGAATCAAAAACTAAAGAAATATAAAGCTGAAAATAAGTATAGAAAAGCAACAGGA
CAAGCGCCAATTAAAGAAGTAATGACACCTACAAATATGAATGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 137 bp

>AT122842 NZ_CP038460:c353460-353324 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTGTAGTTAAAT
GAATTTATATAATCCTCTAACCATCGTACTCGTCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin