Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3335687..3336482 Replicon chromosome
Accession NZ_CP038423
Organism Escherichia coli O157:H7 strain 7409

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag E3151_RS17130 Protein ID WP_000854914.1
Coordinates 3335687..3336061 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag E3151_RS17135 Protein ID WP_001416641.1
Coordinates 3336108..3336482 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3151_RS17090 3330691..3331182 - 492 WP_001301587.1 DUF1097 domain-containing protein -
E3151_RS17095 3331284..3331838 - 555 WP_001001917.1 molecular chaperone YcdY -
E3151_RS17100 3331862..3332599 - 738 WP_000283664.1 zinc-binding phosphatase -
E3151_RS17105 3332654..3333592 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
E3151_RS17115 3334063..3334905 - 843 WP_171877955.1 DUF4942 domain-containing protein -
E3151_RS17120 3334990..3335187 - 198 WP_000839282.1 DUF957 domain-containing protein -
E3151_RS17125 3335199..3335690 - 492 WP_000976853.1 hypothetical protein -
E3151_RS17130 3335687..3336061 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
E3151_RS17135 3336108..3336482 - 375 WP_001416641.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E3151_RS17140 3336645..3336866 - 222 WP_001220314.1 DUF987 domain-containing protein -
E3151_RS17145 3336929..3337405 - 477 WP_001186738.1 RadC family protein -
E3151_RS17150 3337421..3337906 - 486 WP_000214398.1 antirestriction protein -
E3151_RS17155 3337997..3338815 - 819 WP_001234682.1 DUF945 domain-containing protein -
E3151_RS17160 3339155..3340225 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
E3151_RS17165 3340222..3341127 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3327073..3337906 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T122706 WP_000854914.1 NZ_CP038423:c3336061-3335687 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T122706 NZ_CP038423:c3336061-3335687 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13778.61 Da        Isoelectric Point: 6.6249

>AT122706 WP_001416641.1 NZ_CP038423:c3336482-3336108 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGFCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT122706 NZ_CP038423:c3336482-3336108 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTTCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5


Antitoxin

Source ID Structure

References