122568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ldrD-sokW/Ldr(toxin)
Location 292894..293115 Replicon chromosome
Accession NZ_CP038416
Organism Escherichia coli O157:H7 strain 3-5-1

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag E4U90_RS01420 Protein ID WP_001295224.1
Coordinates 293008..293115 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 292894..292959 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U90_RS01400 288334..289236 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
E4U90_RS01405 289247..290230 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
E4U90_RS01410 290227..291231 + 1005 WP_000107027.1 dipeptide ABC transporter ATP-binding subunit DppF -
E4U90_RS01415 291261..292532 - 1272 WP_001301684.1 amino acid permease -
- 292894..292959 - 66 NuclAT_16 - Antitoxin
- 292894..292959 - 66 NuclAT_16 - Antitoxin
- 292894..292959 - 66 NuclAT_16 - Antitoxin
- 292894..292959 - 66 NuclAT_16 - Antitoxin
- 292894..292959 - 66 NuclAT_21 - Antitoxin
- 292894..292959 - 66 NuclAT_21 - Antitoxin
- 292894..292959 - 66 NuclAT_21 - Antitoxin
- 292894..292959 - 66 NuclAT_21 - Antitoxin
E4U90_RS01420 293008..293115 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
E4U90_RS01425 293202..294881 - 1680 WP_000191596.1 cellulose biosynthesis protein BcsG -
E4U90_RS01430 294878..295069 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
E4U90_RS01435 295066..296637 - 1572 Protein_284 cellulose biosynthesis protein BcsE -
E4U90_RS01440 296910..297098 + 189 WP_001063316.1 YhjR family protein -
E4U90_RS01445 297110..297307 + 198 WP_000279508.1 AAA family ATPase -
E4U90_RS01450 297326..297862 + 537 WP_001270903.1 cellulose synthase operon protein YhjQ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-35)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T122568 WP_001295224.1 NZ_CP038416:293008-293115 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T122568 NZ_CP038416:293008-293115 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 66 bp

>AT122568 NZ_CP038416:c292959-292894 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7


Antitoxin

Download structure file

References