Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4850437..4850849 | Replicon | chromosome |
Accession | NZ_CP038414 | ||
Organism | Escherichia coli O157:H7 strain 17B6-2 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | E4U86_RS24200 | Protein ID | WP_000132630.1 |
Coordinates | 4850508..4850849 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4850437..4850513 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4U86_RS24190 | 4847064..4848533 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
E4U86_RS24195 | 4848533..4850287 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 4850437..4850513 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4850437..4850513 | - | 77 | NuclAT_16 | - | Antitoxin |
E4U86_RS24200 | 4850508..4850849 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
E4U86_RS24205 | 4850896..4852059 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
E4U86_RS24210 | 4852107..4852988 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
E4U86_RS24215 | 4853085..4853249 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
E4U86_RS24220 | 4853426..4854838 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
E4U86_RS24225 | 4855081..4855281 | - | 201 | WP_001310455.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4842636..4863779 | 21143 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T122562 WP_000132630.1 NZ_CP038414:4850508-4850849 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T122562 NZ_CP038414:4850508-4850849 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT122562 NZ_CP038414:c4850513-4850437 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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