Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4765775..4766187 Replicon chromosome
Accession NZ_CP038412
Organism Escherichia coli O157:H7 strain 493/89

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag E3172_RS23695 Protein ID WP_000132630.1
Coordinates 4765846..4766187 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4765775..4765851 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3172_RS23685 4762402..4763871 + 1470 WP_001359035.1 type I restriction-modification system subunit M -
E3172_RS23690 4763871..4765625 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4765775..4765851 - 77 NuclAT_15 - Antitoxin
- 4765775..4765851 - 77 NuclAT_15 - Antitoxin
- 4765775..4765851 - 77 NuclAT_15 - Antitoxin
- 4765775..4765851 - 77 NuclAT_15 - Antitoxin
- 4765775..4765851 - 77 NuclAT_16 - Antitoxin
- 4765775..4765851 - 77 NuclAT_16 - Antitoxin
- 4765775..4765851 - 77 NuclAT_16 - Antitoxin
- 4765775..4765851 - 77 NuclAT_16 - Antitoxin
E3172_RS23695 4765846..4766187 + 342 WP_000132630.1 endoribonuclease SymE Toxin
E3172_RS23700 4766234..4767397 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
E3172_RS23705 4767445..4768326 - 882 WP_001304007.1 DUF262 domain-containing protein -
E3172_RS23710 4768423..4768587 - 165 WP_000394274.1 DUF1127 domain-containing protein -
E3172_RS23715 4768764..4769783 + 1020 Protein_4650 PLP-dependent aminotransferase family protein -
E3172_RS23720 4769845..4770996 + 1152 WP_001254932.1 IS30-like element IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4757974..4780390 22416
- flank IS/Tn - - 4769845..4770996 1151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T122519 WP_000132630.1 NZ_CP038412:4765846-4766187 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T122519 NZ_CP038412:4765846-4766187 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT122519 NZ_CP038412:c4765851-4765775 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References