Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ralRA/- |
Location | 2711385..2711756 | Replicon | chromosome |
Accession | NZ_CP038412 | ||
Organism | Escherichia coli O157:H7 strain 493/89 |
Toxin (Protein)
Gene name | ralR | Uniprot ID | F4VC37 |
Locus tag | E3172_RS13585 | Protein ID | WP_001317028.1 |
Coordinates | 2711562..2711756 (-) | Length | 65 a.a. |
Antitoxin (RNA)
Gene name | ralA | ||
Locus tag | - | ||
Coordinates | 2711385..2711563 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3172_RS13555 | 2707137..2707307 | + | 171 | WP_001625136.1 | hypothetical protein | - |
E3172_RS13560 | 2707340..2708713 | + | 1374 | WP_000123747.1 | ATP-dependent RNA helicase DbpA | - |
E3172_RS13565 | 2708842..2709777 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
E3172_RS13570 | 2709829..2711064 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
E3172_RS13575 | 2711066..2711281 | - | 216 | WP_000079604.1 | excisionase XisR | - |
E3172_RS13580 | 2711360..2711569 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
- | 2711385..2711563 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2711385..2711563 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2711385..2711563 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2711385..2711563 | + | 179 | NuclAT_0 | - | Antitoxin |
E3172_RS13585 | 2711562..2711756 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
E3172_RS13590 | 2711813..2712622 | - | 810 | WP_000595430.1 | recombination protein RecT | - |
E3172_RS13595 | 2712615..2715290 | - | 2676 | WP_000105108.1 | exodeoxyribonuclease VIII | - |
E3172_RS13600 | 2715392..2715668 | - | 277 | Protein_2666 | hypothetical protein | - |
E3172_RS13605 | 2715743..2715919 | - | 177 | WP_000245528.1 | hypothetical protein | - |
E3172_RS13610 | 2715913..2716134 | - | 222 | WP_000560227.1 | cell division protein FtsZ | - |
E3172_RS13615 | 2716543..2716695 | - | 153 | WP_000379547.1 | DUF1391 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2709829..2753484 | 43655 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T122498 WP_001317028.1 NZ_CP038412:c2711756-2711562 [Escherichia coli O157:H7]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T122498 NZ_CP038412:c2711756-2711562 [Escherichia coli O157:H7]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT122498 NZ_CP038412:2711385-2711563 [Escherichia coli O157:H7]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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