Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
Location | 4434571..4435110 | Replicon | chromosome |
Accession | NZ_CP038405 | ||
Organism | Escherichia coli O157:H7 strain ATCC 35150 |
Toxin (Protein)
Gene name | yafQ | Uniprot ID | - |
Locus tag | E3153_RS22365 | Protein ID | WP_001303998.1 |
Coordinates | 4434850..4435110 (+) | Length | 87 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | C3TP07 |
Locus tag | E3153_RS22360 | Protein ID | WP_000729705.1 |
Coordinates | 4434571..4434831 (+) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3153_RS22340 | 4430325..4431110 | - | 786 | WP_000207556.1 | putative lateral flagellar export/assembly protein LafU | - |
E3153_RS22345 | 4431055..4432794 | + | 1740 | WP_001301901.1 | flagellar biosynthesis protein FlhA | - |
E3153_RS22350 | 4432939..4433436 | - | 498 | Protein_4378 | REP-associated tyrosine transposase RayT | - |
E3153_RS22355 | 4433612..4434385 | - | 774 | WP_000543891.1 | C40 family peptidase | - |
E3153_RS22360 | 4434571..4434831 | + | 261 | WP_000729705.1 | type II toxin-antitoxin system antitoxin DinJ | Antitoxin |
E3153_RS22365 | 4434850..4435110 | + | 261 | WP_001303998.1 | type II toxin-antitoxin system mRNA interferase toxin YafQ | Toxin |
E3153_RS22370 | 4435266..4436006 | + | 741 | WP_001225679.1 | murein L,D-transpeptidase | - |
E3153_RS22375 | 4435977..4436744 | - | 768 | WP_001301698.1 | class II glutamine amidotransferase | - |
E3153_RS22380 | 4436849..4437427 | - | 579 | WP_000284050.1 | D-sedoheptulose 7-phosphate isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10026.71 Da Isoelectric Point: 10.3188
>T122450 WP_001303998.1 NZ_CP038405:4434850-4435110 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG
Download Length: 261 bp
>T122450 NZ_CP038405:4434850-4435110 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9377.74 Da Isoelectric Point: 5.0758
>AT122450 WP_000729705.1 NZ_CP038405:4434571-4434831 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV
Download Length: 261 bp
>AT122450 NZ_CP038405:4434571-4434831 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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