Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 4104712..4105406 Replicon chromosome
Accession NZ_CP038386
Organism Escherichia coli O157:H7 strain DEC5D

Toxin (Protein)


Gene name yafO Uniprot ID C3TNX7
Locus tag E3157_RS19895 Protein ID WP_001263495.1
Coordinates 4104712..4105110 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag E3157_RS19900 Protein ID WP_000554757.1
Coordinates 4105113..4105406 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- 4100299..4100379 - 81 NuclAT_10 - -
- 4100299..4100379 - 81 NuclAT_10 - -
- 4100299..4100379 - 81 NuclAT_10 - -
- 4100299..4100379 - 81 NuclAT_10 - -
E3157_RS19870 4100975..4101433 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
E3157_RS19875 4101694..4103151 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
E3157_RS19880 4103208..4103765 - 558 WP_023438539.1 peptide chain release factor H -
E3157_RS19885 4103677..4103943 - 267 WP_001303804.1 hypothetical protein -
E3157_RS19890 4104250..4104702 - 453 WP_001059871.1 GNAT family N-acetyltransferase -
E3157_RS19895 4104712..4105110 - 399 WP_001263495.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
E3157_RS19900 4105113..4105406 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
E3157_RS19905 4105458..4106513 - 1056 WP_001226186.1 DNA polymerase IV -
E3157_RS19910 4106584..4107369 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
E3157_RS19915 4107314..4107658 + 345 Protein_3902 FHIPEP family type III secretion protein -
E3157_RS19920 4107955..4108452 - 498 Protein_3903 REP-associated tyrosine transposase RayT -
E3157_RS19925 4108628..4109401 - 774 WP_000543891.1 C40 family peptidase -
E3157_RS19930 4109587..4109847 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ -
E3157_RS19935 4109850..4110128 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-130)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15473.86 Da        Isoelectric Point: 8.0949

>T122278 WP_001263495.1 NZ_CP038386:c4105110-4104712 [Escherichia coli O157:H7]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDESHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T122278 NZ_CP038386:c4105110-4104712 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT122278 WP_000554757.1 NZ_CP038386:c4105406-4105113 [Escherichia coli O157:H7]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT122278 NZ_CP038386:c4105406-4105113 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References