Detailed information of TA system TA122144

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 5176152..5176373
• Replicon: chromosome
• Accession: NZ_CP038374
• Organism: Escherichia coli O157:H7 strain F3113

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: E3160_RS25420
• Protein ID: WP_001295224.1
• Coordinates: 5176152..5176259 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	5176308..5176373 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3160_RS25395	5171405..5172157	-	753	WP_000279530.1	cellulose biosynthesis protein BcsQ	-
E3160_RS25400	5172169..5172357	-	189	WP_001063316.1	YhjR family protein	-
E3160_RS25405	5172630..5174201	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
E3160_RS25410	5174198..5174389	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
E3160_RS25415	5174386..5176065	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
E3160_RS25420	5176152..5176259	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	5176308..5176373	+	66	NuclAT_17	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_17	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_17	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_17	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_22	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_22	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_22	-	Antitoxin
-	5176308..5176373	+	66	NuclAT_22	-	Antitoxin
E3160_RS25425	5176735..5178006	+	1272	WP_001306601.1	amino acid permease	-
E3160_RS25430	5178036..5179040	-	1005	WP_171880495.1	dipeptide ABC transporter ATP-binding subunit DppF	-
E3160_RS25435	5179037..5180020	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
E3160_RS25440	5180031..5180933	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T122144 WP_001295224.1 NZ_CP038374:c5176259-5176152 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T122144 NZ_CP038374:c5176259-5176152 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT122144 NZ_CP038374:5176308-5176373 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin