Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 716506..716918 Replicon chromosome
Accession NZ_CP038374
Organism Escherichia coli O157:H7 strain F3113

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag E3160_RS03295 Protein ID WP_000132630.1
Coordinates 716506..716847 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 716842..716918 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3160_RS03270 712074..712274 + 201 WP_001310455.1 hypothetical protein -
E3160_RS03275 712517..713929 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
E3160_RS03280 714106..714270 + 165 WP_000394274.1 DUF1127 domain-containing protein -
E3160_RS03285 714367..715248 + 882 WP_001476351.1 DUF262 domain-containing protein -
E3160_RS03290 715296..716459 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
E3160_RS03295 716506..716847 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 716842..716918 + 77 NuclAT_15 - Antitoxin
- 716842..716918 + 77 NuclAT_15 - Antitoxin
- 716842..716918 + 77 NuclAT_15 - Antitoxin
- 716842..716918 + 77 NuclAT_15 - Antitoxin
- 716842..716918 + 77 NuclAT_16 - Antitoxin
- 716842..716918 + 77 NuclAT_16 - Antitoxin
- 716842..716918 + 77 NuclAT_16 - Antitoxin
- 716842..716918 + 77 NuclAT_16 - Antitoxin
E3160_RS03300 717068..718822 - 1755 WP_000110082.1 restriction endonuclease subunit S -
E3160_RS03305 718822..720291 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 705999..724719 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T122114 WP_000132630.1 NZ_CP038374:c716847-716506 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T122114 NZ_CP038374:c716847-716506 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT122114 NZ_CP038374:716842-716918 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References