Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4913651..4914063 Replicon chromosome
Accession NZ_CP038372
Organism Escherichia coli O157:H7 strain F6294

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag E3161_RS24805 Protein ID WP_000132630.1
Coordinates 4913722..4914063 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4913651..4913727 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3161_RS24795 4910278..4911747 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
E3161_RS24800 4911747..4913501 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4913651..4913727 - 77 NuclAT_16 - Antitoxin
- 4913651..4913727 - 77 NuclAT_16 - Antitoxin
- 4913651..4913727 - 77 NuclAT_16 - Antitoxin
- 4913651..4913727 - 77 NuclAT_16 - Antitoxin
- 4913651..4913727 - 77 NuclAT_17 - Antitoxin
- 4913651..4913727 - 77 NuclAT_17 - Antitoxin
- 4913651..4913727 - 77 NuclAT_17 - Antitoxin
- 4913651..4913727 - 77 NuclAT_17 - Antitoxin
E3161_RS24805 4913722..4914063 + 342 WP_000132630.1 endoribonuclease SymE Toxin
E3161_RS24810 4914110..4915273 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
E3161_RS24815 4915321..4916202 - 882 WP_001304007.1 DUF262 domain-containing protein -
E3161_RS24820 4916299..4916463 - 165 WP_000394274.1 DUF1127 domain-containing protein -
E3161_RS24825 4916640..4918052 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
E3161_RS24830 4918295..4918495 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4905850..4927089 21239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T122106 WP_000132630.1 NZ_CP038372:4913722-4914063 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T122106 NZ_CP038372:4913722-4914063 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT122106 NZ_CP038372:c4913727-4913651 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References