Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2511149..2511620 | Replicon | chromosome |
Accession | NZ_CP038372 | ||
Organism | Escherichia coli O157:H7 strain F6294 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | E3161_RS12515 | Protein ID | WP_001303511.1 |
Coordinates | 2511149..2511427 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | E3161_RS12520 | Protein ID | WP_001302048.1 |
Coordinates | 2511429..2511620 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3161_RS12480 | 2506374..2506625 | - | 252 | WP_000005552.1 | excisionase family protein | - |
E3161_RS12485 | 2506698..2509169 | - | 2472 | WP_000048458.1 | exonuclease | - |
E3161_RS12490 | 2509262..2509453 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
E3161_RS12495 | 2509450..2509638 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
E3161_RS12500 | 2510039..2510203 | + | 165 | WP_001331716.1 | hypothetical protein | - |
E3161_RS12505 | 2510207..2510425 | - | 219 | WP_001171930.1 | hypothetical protein | - |
E3161_RS12510 | 2510497..2510796 | - | 300 | WP_001240334.1 | hypothetical protein | - |
E3161_RS12515 | 2511149..2511427 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E3161_RS12520 | 2511429..2511620 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
E3161_RS12525 | 2511641..2512012 | - | 372 | WP_001169686.1 | hypothetical protein | - |
E3161_RS12530 | 2512110..2512412 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
E3161_RS12535 | 2512409..2512834 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
E3161_RS12540 | 2512857..2513819 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
E3161_RS12545 | 2513826..2514566 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
E3161_RS12550 | 2514592..2515361 | + | 770 | Protein_2454 | DUF1627 domain-containing protein | - |
E3161_RS12555 | 2515377..2515772 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
E3161_RS12560 | 2515829..2516413 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | nleG7' | 2502862..2603504 | 100642 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T122097 WP_001303511.1 NZ_CP038372:c2511427-2511149 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T122097 NZ_CP038372:c2511427-2511149 [Escherichia coli O157:H7]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT122097 WP_001302048.1 NZ_CP038372:c2511620-2511429 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT122097 NZ_CP038372:c2511620-2511429 [Escherichia coli O157:H7]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|