122074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4839142..4839554 Replicon chromosome
Accession NZ_CP038369
Organism Escherichia coli O157:H7 strain F6321

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag E3162_RS24365 Protein ID WP_000132630.1
Coordinates 4839213..4839554 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4839142..4839218 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3162_RS24355 4835769..4837238 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
E3162_RS24360 4837238..4838992 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4839142..4839218 - 77 NuclAT_15 - Antitoxin
- 4839142..4839218 - 77 NuclAT_15 - Antitoxin
- 4839142..4839218 - 77 NuclAT_15 - Antitoxin
- 4839142..4839218 - 77 NuclAT_15 - Antitoxin
- 4839142..4839218 - 77 NuclAT_16 - Antitoxin
- 4839142..4839218 - 77 NuclAT_16 - Antitoxin
- 4839142..4839218 - 77 NuclAT_16 - Antitoxin
- 4839142..4839218 - 77 NuclAT_16 - Antitoxin
E3162_RS24365 4839213..4839554 + 342 WP_000132630.1 endoribonuclease SymE Toxin
E3162_RS24370 4839601..4840764 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
E3162_RS24375 4840812..4841693 - 882 WP_001304007.1 DUF262 domain-containing protein -
E3162_RS24380 4841790..4841954 - 165 WP_000394274.1 DUF1127 domain-containing protein -
E3162_RS24385 4842131..4843543 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4827067..4852555 25488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T122074 WP_000132630.1 NZ_CP038369:4839213-4839554 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T122074 NZ_CP038369:4839213-4839554 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT122074 NZ_CP038369:c4839218-4839142 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References