Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4825742..4826154 | Replicon | chromosome |
Accession | NZ_CP038366 | ||
Organism | Escherichia coli O157:H7 strain F6667 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | E4U72_RS24185 | Protein ID | WP_000132630.1 |
Coordinates | 4825813..4826154 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4825742..4825818 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4U72_RS24175 | 4822369..4823838 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
E4U72_RS24180 | 4823838..4825592 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 4825742..4825818 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_14 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4825742..4825818 | - | 77 | NuclAT_15 | - | Antitoxin |
E4U72_RS24185 | 4825813..4826154 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
E4U72_RS24190 | 4826201..4827364 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
E4U72_RS24195 | 4827412..4828293 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
E4U72_RS24200 | 4828390..4828554 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
E4U72_RS24205 | 4828731..4830143 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4817941..4839161 | 21220 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T122041 WP_000132630.1 NZ_CP038366:4825813-4826154 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T122041 NZ_CP038366:4825813-4826154 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT122041 NZ_CP038366:c4825818-4825742 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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