Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ralRA/- |
Location | 2579438..2579809 | Replicon | chromosome |
Accession | NZ_CP038349 | ||
Organism | Escherichia coli O157:H7 strain F8952 |
Toxin (Protein)
Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
Locus tag | E4U62_RS12710 | Protein ID | WP_001443846.1 |
Coordinates | 2579660..2579809 (-) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | ralA | ||
Locus tag | - | ||
Coordinates | 2579438..2579616 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E4U62_RS12680 | 2575190..2575360 | + | 171 | WP_001625136.1 | hypothetical protein | - |
E4U62_RS12685 | 2575393..2576766 | + | 1374 | WP_000123746.1 | ATP-dependent RNA helicase DbpA | - |
E4U62_RS12690 | 2576895..2577830 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
E4U62_RS12695 | 2577882..2579117 | - | 1236 | WP_000040839.1 | site-specific integrase | - |
E4U62_RS12700 | 2579119..2579334 | - | 216 | WP_000079604.1 | excisionase XisR | - |
E4U62_RS12705 | 2579434..2579622 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
- | 2579438..2579616 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2579438..2579616 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2579438..2579616 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 2579438..2579616 | + | 179 | NuclAT_0 | - | Antitoxin |
E4U62_RS12710 | 2579660..2579809 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
E4U62_RS12715 | 2579865..2580674 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
E4U62_RS12720 | 2580667..2583267 | - | 2601 | WP_000105140.1 | exodeoxyribonuclease VIII | - |
E4U62_RS12725 | 2583369..2583644 | - | 276 | WP_001344816.1 | hypothetical protein | - |
E4U62_RS12730 | 2583719..2583889 | - | 171 | WP_001352098.1 | conserved protein, Rac prophage | - |
E4U62_RS12735 | 2583889..2584110 | - | 222 | WP_000560223.1 | killing protein KilR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2565619..2629945 | 64326 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T121780 WP_001443846.1 NZ_CP038349:c2579809-2579660 [Escherichia coli O157:H7]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T121780 NZ_CP038349:c2579809-2579660 [Escherichia coli O157:H7]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT121780 NZ_CP038349:2579438-2579616 [Escherichia coli O157:H7]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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