121718

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4718479..4718891 Replicon chromosome
Accession NZ_CP038344
Organism Escherichia coli O157:H7 strain Gim1-1

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag E4U63_RS23385 Protein ID WP_000132630.1
Coordinates 4718550..4718891 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4718479..4718555 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U63_RS23375 4715106..4716575 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
E4U63_RS23380 4716575..4718329 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4718479..4718555 - 77 NuclAT_14 - Antitoxin
- 4718479..4718555 - 77 NuclAT_14 - Antitoxin
- 4718479..4718555 - 77 NuclAT_14 - Antitoxin
- 4718479..4718555 - 77 NuclAT_14 - Antitoxin
- 4718479..4718555 - 77 NuclAT_15 - Antitoxin
- 4718479..4718555 - 77 NuclAT_15 - Antitoxin
- 4718479..4718555 - 77 NuclAT_15 - Antitoxin
- 4718479..4718555 - 77 NuclAT_15 - Antitoxin
E4U63_RS23385 4718550..4718891 + 342 WP_000132630.1 endoribonuclease SymE Toxin
E4U63_RS23390 4718938..4720101 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
E4U63_RS23395 4720149..4721030 - 882 WP_001304007.1 DUF262 domain-containing protein -
E4U63_RS23400 4721127..4721291 - 165 WP_000394274.1 DUF1127 domain-containing protein -
E4U63_RS23405 4721468..4722880 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
E4U63_RS23410 4723123..4723323 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4710678..4731887 21209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T121718 WP_000132630.1 NZ_CP038344:4718550-4718891 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T121718 NZ_CP038344:4718550-4718891 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT121718 NZ_CP038344:c4718555-4718479 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References