Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4778026..4778438 Replicon chromosome
Accession NZ_CP038342
Organism Escherichia coli O157:H7 strain H2495

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag E3163_RS23915 Protein ID WP_000132630.1
Coordinates 4778097..4778438 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4778026..4778102 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3163_RS23905 4774653..4776122 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
E3163_RS23910 4776122..4777876 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4778026..4778102 - 77 NuclAT_15 - Antitoxin
- 4778026..4778102 - 77 NuclAT_15 - Antitoxin
- 4778026..4778102 - 77 NuclAT_15 - Antitoxin
- 4778026..4778102 - 77 NuclAT_15 - Antitoxin
- 4778026..4778102 - 77 NuclAT_16 - Antitoxin
- 4778026..4778102 - 77 NuclAT_16 - Antitoxin
- 4778026..4778102 - 77 NuclAT_16 - Antitoxin
- 4778026..4778102 - 77 NuclAT_16 - Antitoxin
E3163_RS23915 4778097..4778438 + 342 WP_000132630.1 endoribonuclease SymE Toxin
E3163_RS23920 4778485..4779648 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
E3163_RS23925 4779696..4780577 - 882 WP_001304007.1 DUF262 domain-containing protein -
E3163_RS23930 4780674..4780838 - 165 WP_000394274.1 DUF1127 domain-containing protein -
E3163_RS23935 4781015..4782427 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
E3163_RS23940 4782670..4782870 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4770225..4791452 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T121681 WP_000132630.1 NZ_CP038342:4778097-4778438 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T121681 NZ_CP038342:4778097-4778438 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT121681 NZ_CP038342:c4778102-4778026 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References