Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4795383..4795795 Replicon chromosome
Accession NZ_CP038336
Organism Escherichia coli O157:H7 strain LSU61

Toxin (Protein)


Gene name symE Uniprot ID -
Locus tag E3165_RS23860 Protein ID WP_000132626.1
Coordinates 4795454..4795795 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4795383..4795459 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3165_RS23850 4792010..4793479 + 1470 WP_001359936.1 type I restriction-modification system subunit M -
E3165_RS23855 4793479..4795233 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4795383..4795459 - 77 NuclAT_14 - Antitoxin
- 4795383..4795459 - 77 NuclAT_14 - Antitoxin
- 4795383..4795459 - 77 NuclAT_14 - Antitoxin
- 4795383..4795459 - 77 NuclAT_14 - Antitoxin
- 4795383..4795459 - 77 NuclAT_15 - Antitoxin
- 4795383..4795459 - 77 NuclAT_15 - Antitoxin
- 4795383..4795459 - 77 NuclAT_15 - Antitoxin
- 4795383..4795459 - 77 NuclAT_15 - Antitoxin
E3165_RS23860 4795454..4795795 + 342 WP_000132626.1 endoribonuclease SymE Toxin
E3165_RS23865 4795842..4797005 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
E3165_RS23870 4797053..4797934 - 882 WP_001304007.1 DUF262 domain-containing protein -
E3165_RS23875 4798031..4798195 - 165 WP_000394274.1 DUF1127 domain-containing protein -
E3165_RS23880 4798372..4799478 + 1107 WP_171877365.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
E3165_RS23885 4799398..4800549 - 1152 WP_001254932.1 IS30-like element IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 / espX6 4787583..4810024 22441
- flank IS/Tn - - 4799398..4800549 1151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12326.19 Da        Isoelectric Point: 8.4982

>T121607 WP_000132626.1 NZ_CP038336:4795454-4795795 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTMVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T121607 NZ_CP038336:4795454-4795795 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGATGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT121607 NZ_CP038336:c4795459-4795383 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References