Detailed information of TA system TA121576

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 277100..277321
• Replicon: chromosome
• Accession: NZ_CP038336
• Organism: Escherichia coli O157:H7 strain LSU61

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: E3165_RS01330
• Protein ID: WP_001295224.1
• Coordinates: 277214..277321 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	277100..277165 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3165_RS01310	272540..273442	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
E3165_RS01315	273453..274436	+	984	WP_001196476.1	dipeptide ABC transporter ATP-binding protein	-
E3165_RS01320	274433..275437	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
E3165_RS01325	275467..276738	-	1272	WP_001306601.1	amino acid permease	-
-	277100..277165	-	66	NuclAT_16	-	Antitoxin
-	277100..277165	-	66	NuclAT_16	-	Antitoxin
-	277100..277165	-	66	NuclAT_16	-	Antitoxin
-	277100..277165	-	66	NuclAT_16	-	Antitoxin
-	277100..277165	-	66	NuclAT_21	-	Antitoxin
-	277100..277165	-	66	NuclAT_21	-	Antitoxin
-	277100..277165	-	66	NuclAT_21	-	Antitoxin
-	277100..277165	-	66	NuclAT_21	-	Antitoxin
E3165_RS01330	277214..277321	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
E3165_RS01335	277408..279087	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
E3165_RS01340	279084..279275	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
E3165_RS01345	279272..280843	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
E3165_RS01350	281116..281304	+	189	WP_001063314.1	YhjR family protein	-
E3165_RS01355	281316..282068	+	753	WP_000279530.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T121576 WP_001295224.1 NZ_CP038336:277214-277321 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T121576 NZ_CP038336:277214-277321 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT121576 NZ_CP038336:c277165-277100 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin