Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 21509..22166 | Replicon | plasmid pNE1169-3 |
| Accession | NZ_CP038326 | ||
| Organism | Escherichia coli O157:H7 strain NE 1169-1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | E4U74_RS27315 | Protein ID | WP_000270043.1 |
| Coordinates | 21509..21859 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | E4U74_RS27320 | Protein ID | WP_000124640.1 |
| Coordinates | 21864..22166 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E4U74_RS27270 | 16820..16999 | + | 180 | Protein_19 | helix-turn-helix transcriptional regulator | - |
| E4U74_RS27275 | 17064..17768 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| E4U74_RS27280 | 17983..18480 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| E4U74_RS27285 | 18483..18971 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| E4U74_RS27290 | 19068..19403 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| E4U74_RS27295 | 19418..19888 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| E4U74_RS27300 | 19881..20252 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| E4U74_RS27305 | 20263..20457 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| E4U74_RS27310 | 20798..21346 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| E4U74_RS27315 | 21509..21859 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| E4U74_RS27320 | 21864..22166 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| E4U74_RS27325 | 22193..22486 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| E4U74_RS27330 | 22574..22846 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| E4U74_RS27335 | 22904..23431 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| E4U74_RS27340 | 23662..24519 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| E4U74_RS27345 | 24506..24736 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| E4U74_RS27350 | 24736..25254 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| E4U74_RS27355 | 25251..25697 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| E4U74_RS27360 | 25697..26056 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| E4U74_RS27365 | 26113..26541 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | dfrA23 / sul1 / qacE / aadA2 / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | - | 1..145329 | 145329 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T121505 WP_000270043.1 NZ_CP038326:21509-21859 [Escherichia coli O157:H7]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T121505 NZ_CP038326:21509-21859 [Escherichia coli O157:H7]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT121505 WP_000124640.1 NZ_CP038326:21864-22166 [Escherichia coli O157:H7]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT121505 NZ_CP038326:21864-22166 [Escherichia coli O157:H7]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|