Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ldrD-sokW/Ldr(toxin)
Location 277050..277271 Replicon chromosome
Accession NZ_CP038305
Organism Escherichia coli O157:H7 strain SS NE 1040-1

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag E4U78_RS01320 Protein ID WP_001295224.1
Coordinates 277164..277271 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 277050..277115 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4U78_RS01300 272496..273398 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
E4U78_RS01305 273409..274392 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
E4U78_RS01310 274389..275393 + 1005 WP_000107027.1 dipeptide ABC transporter ATP-binding subunit DppF -
E4U78_RS01315 275423..276688 - 1266 WP_001481782.1 amino acid permease -
- 277050..277115 - 66 NuclAT_16 - Antitoxin
- 277050..277115 - 66 NuclAT_16 - Antitoxin
- 277050..277115 - 66 NuclAT_16 - Antitoxin
- 277050..277115 - 66 NuclAT_16 - Antitoxin
- 277050..277115 - 66 NuclAT_21 - Antitoxin
- 277050..277115 - 66 NuclAT_21 - Antitoxin
- 277050..277115 - 66 NuclAT_21 - Antitoxin
- 277050..277115 - 66 NuclAT_21 - Antitoxin
E4U78_RS01320 277164..277271 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
E4U78_RS01325 277358..279037 - 1680 WP_000191592.1 cellulose biosynthesis protein BcsG -
E4U78_RS01330 279034..279225 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
E4U78_RS01335 279222..280793 - 1572 WP_001204920.1 cellulose biosynthesis protein BcsE -
E4U78_RS01340 281066..281254 + 189 WP_001063316.1 YhjR family protein -
E4U78_RS01345 281266..281463 + 198 WP_000279508.1 AAA family ATPase -
E4U78_RS01350 281482..282018 + 537 WP_001270903.1 cellulose synthase operon protein YhjQ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-35)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T121251 WP_001295224.1 NZ_CP038305:277164-277271 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T121251 NZ_CP038305:277164-277271 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 66 bp

>AT121251 NZ_CP038305:c277115-277050 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7


Antitoxin

Download structure file

References