Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 4178766..4179460 | Replicon | chromosome |
| Accession | NZ_CP038295 | ||
| Organism | Escherichia coli O157:H7 strain TB182A | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | C3TNX7 |
| Locus tag | E3171_RS20375 | Protein ID | WP_001263495.1 |
| Coordinates | 4178766..4179164 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | E3171_RS20380 | Protein ID | WP_000554757.1 |
| Coordinates | 4179167..4179460 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - | 4174353..4174433 | - | 81 | NuclAT_11 | - | - |
| - | 4174353..4174433 | - | 81 | NuclAT_11 | - | - |
| - | 4174353..4174433 | - | 81 | NuclAT_11 | - | - |
| - | 4174353..4174433 | - | 81 | NuclAT_11 | - | - |
| E3171_RS20350 | 4175029..4175487 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| E3171_RS20355 | 4175748..4177205 | + | 1458 | WP_001293009.1 | cytosol nonspecific dipeptidase | - |
| E3171_RS20360 | 4177262..4177819 | - | 558 | WP_023438539.1 | peptide chain release factor H | - |
| E3171_RS20365 | 4177731..4177997 | - | 267 | WP_001303804.1 | hypothetical protein | - |
| E3171_RS20370 | 4178304..4178756 | - | 453 | WP_001059871.1 | GNAT family N-acetyltransferase | - |
| E3171_RS20375 | 4178766..4179164 | - | 399 | WP_001263495.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| E3171_RS20380 | 4179167..4179460 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| E3171_RS20385 | 4179512..4180567 | - | 1056 | WP_001226186.1 | DNA polymerase IV | - |
| E3171_RS20390 | 4180638..4181423 | - | 786 | WP_000207556.1 | putative lateral flagellar export/assembly protein LafU | - |
| E3171_RS20395 | 4181368..4181712 | + | 345 | Protein_3995 | FHIPEP family type III secretion protein | - |
| E3171_RS20400 | 4182009..4182506 | - | 498 | Protein_3996 | REP-associated tyrosine transposase RayT | - |
| E3171_RS20405 | 4182682..4183455 | - | 774 | WP_000543891.1 | C40 family peptidase | - |
| E3171_RS20410 | 4183641..4183901 | + | 261 | WP_000729705.1 | type II toxin-antitoxin system antitoxin DinJ | - |
| E3171_RS20415 | 4183904..4184182 | + | 279 | WP_000615979.1 | type II toxin-antitoxin system mRNA interferase toxin YafQ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espK / espK / nleB2 / espM2 / espW / flhA | 4105057..4183455 | 78398 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15473.86 Da Isoelectric Point: 8.0949
>T121171 WP_001263495.1 NZ_CP038295:c4179164-4178766 [Escherichia coli O157:H7]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDESHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDESHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T121171 NZ_CP038295:c4179164-4178766 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT121171 WP_000554757.1 NZ_CP038295:c4179460-4179167 [Escherichia coli O157:H7]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT121171 NZ_CP038295:c4179460-4179167 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|