Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1388415..1389065 Replicon chromosome
Accession NZ_CP038281
Organism Raoultella ornithinolytica strain WLK218

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4K08_RS10165 Protein ID WP_088402264.1
Coordinates 1388415..1388756 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4K08_RS10170 Protein ID WP_088402265.1
Coordinates 1388766..1389065 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K08_RS10140 1383730..1384161 - 432 Protein_1260 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
E4K08_RS10145 1384266..1385213 + 948 WP_088213165.1 IS30 family transposase -
E4K08_RS10150 1385249..1385878 - 630 Protein_1262 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
E4K08_RS10155 1385901..1386440 - 540 WP_175406685.1 type I-E CRISPR-associated protein Cse2/CasB -
E4K08_RS10160 1386520..1388055 - 1536 WP_137056093.1 type I-E CRISPR-associated protein Cse1/CasA -
E4K08_RS10165 1388415..1388756 + 342 WP_088402264.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4K08_RS10170 1388766..1389065 + 300 WP_088402265.1 helix-turn-helix transcriptional regulator Antitoxin
E4K08_RS10175 1389158..1391863 + 2706 WP_103073080.1 CRISPR-associated helicase/endonuclease Cas3 -
E4K08_RS10180 1391918..1392652 - 735 WP_004866964.1 phosphoadenosine phosphosulfate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12985.68 Da        Isoelectric Point: 5.1498

>T120944 WP_088402264.1 NZ_CP038281:1388415-1388756 [Raoultella ornithinolytica]
MWDIETTDAFDEWFAAQTGTLQEDMLAAMVILSEYGPQLGRPFADTVNDSAFPNMKELRVQHQGNPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYRDMLRLADNEYRKHLNK

Download         Length: 342 bp

>T120944 NZ_CP038281:1388415-1388756 [Raoultella ornithinolytica]
ATGTGGGACATAGAAACGACGGACGCTTTCGATGAGTGGTTTGCGGCACAGACGGGTACGCTGCAGGAAGACATGCTGGC
CGCTATGGTGATTTTATCTGAGTATGGCCCACAGTTAGGCAGGCCGTTTGCAGATACCGTGAATGATTCTGCTTTTCCGA
ACATGAAAGAATTGCGCGTACAGCATCAAGGCAACCCAATCCGAGCCTTCTTTGCGTTTGATCCTTCCCGCCATGGCATC
GTGCTATGCGCCGGAGACAAAACGGGGTTGAACGAAAAGAAATTTTACAGAGACATGCTCAGGCTTGCCGATAATGAATA
CCGTAAGCACCTGAATAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.85 Da        Isoelectric Point: 8.6005

>AT120944 WP_088402265.1 NZ_CP038281:1388766-1389065 [Raoultella ornithinolytica]
MATLKELMAKQSPESRERIAEKVEELRQTIALNMLREELNISQTELAAAMGVKQPTVAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp

>AT120944 NZ_CP038281:1388766-1389065 [Raoultella ornithinolytica]
ATGGCTACCCTTAAAGAACTGATGGCTAAGCAAAGTCCAGAAAGCCGGGAGCGTATTGCCGAAAAAGTGGAAGAACTTCG
CCAGACGATCGCTTTAAACATGCTTAGGGAAGAGCTGAATATTTCTCAAACGGAGCTGGCGGCGGCGATGGGCGTTAAGC
AGCCAACGGTCGCAAAAATGGAGCAGGCAGATAACGATCCCCGCCTGTCGACCCTGAAACGTTACGTCACCGCTCTGGGC
GGCGAACTCAGTATTGACGTGAAGCTCCCAACGGGCAAAAGGGTCGCATTTCACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References