120929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2629538..2630778 Replicon chromosome
Accession NZ_CP038273
Organism Legionella israelensis strain Bercovier 4

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W0W516
Locus tag E4T55_RS12085 Protein ID WP_058501365.1
Coordinates 2629538..2630473 (-) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W0W527
Locus tag E4T55_RS12090 Protein ID WP_058501364.1
Coordinates 2630470..2630778 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4T55_RS12065 2625484..2626383 - 900 WP_058501368.1 integrase domain-containing protein -
E4T55_RS12070 2626376..2627179 - 804 WP_058501367.1 integrase -
E4T55_RS12080 2628408..2629537 + 1130 Protein_2371 integrase family protein -
E4T55_RS12085 2629538..2630473 - 936 WP_058501365.1 HipA domain-containing protein Toxin
E4T55_RS12090 2630470..2630778 - 309 WP_058501364.1 HipA N-terminal domain-containing protein Antitoxin
E4T55_RS12095 2630775..2631002 - 228 WP_058501363.1 helix-turn-helix transcriptional regulator -
E4T55_RS15340 2631603..2632292 - 690 WP_058501362.1 DUF3330 domain-containing protein -
E4T55_RS12105 2632313..2632555 - 243 WP_082636501.1 NAD-binding protein -
E4T55_RS12110 2634010..2634663 - 654 WP_082636502.1 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(3-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 36056.82 Da        Isoelectric Point: 9.4408

>T120929 WP_058501365.1 NZ_CP038273:c2630473-2629538 [Legionella israelensis]
MKRCPITYERIGDREHYSQRGLHLLSPKLKSLSPLNLSADEQRQEAIARVGKMSIQGVQKKLSAKLKVKDGYFEIVDQNG
HYILKPQSDIYPELPENEAITMSLAKTIGLEVPVHGLVYSKDNSMTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDKKISISPAYDLLNSTIAQKNTKEEMALPLKG
KKNNLTQRDFLIYFAIEKLELNQNVIDGILQDFHQVIPQWQELIGSSFLSQHMQERYLQLLDKRCERLNIF

Download         Length: 936 bp

>T120929 NZ_CP038273:c2630473-2629538 [Legionella israelensis]
ATGAAACGCTGCCCCATTACGTATGAAAGGATTGGTGACCGAGAACACTATTCGCAACGTGGATTGCATTTGCTTTCCCC
TAAATTAAAAAGCCTTAGTCCATTAAACTTAAGTGCTGATGAGCAGCGGCAGGAAGCAATTGCTCGTGTAGGGAAGATGT
CTATTCAAGGTGTTCAAAAGAAACTAAGCGCAAAACTAAAGGTTAAAGATGGGTATTTTGAAATCGTTGATCAAAATGGT
CATTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTACCCGAAAATGAAGCCATTACTATGTCCCTTGCAAAAAC
CATTGGTCTTGAAGTACCGGTTCATGGTTTAGTTTATTCTAAAGATAACAGTATGACCTACTTCATTAAACGGTTTGATC
GAATAGGCCATAATAAAAAGCTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGTCACACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAGTCATAGAACAGTTTTGTACATTTCCAAAAATTGAGTTCGTTAAATTATTTAAGTTGAC
ATTGTTTAACTTCCTGGTCGGCAATGAAGACATGCATTTAAAAAATTTTTCCTTAATTACTAAGGATAAAAAAATTTCCA
TATCACCAGCATATGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATGGCTTTGCCCCTCAAAGGG
AAAAAAAATAATTTAACACAGCGTGATTTTCTTATATATTTTGCCATTGAAAAATTAGAATTAAACCAGAACGTTATCGA
TGGGATCCTACAAGATTTTCATCAAGTAATACCTCAATGGCAAGAACTGATTGGTTCAAGTTTTTTATCTCAACATATGC
AGGAAAGATATCTCCAATTGTTAGATAAAAGATGCGAGCGATTAAATATTTTTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11543.40 Da        Isoelectric Point: 4.8096

>AT120929 WP_058501364.1 NZ_CP038273:c2630778-2630470 [Legionella israelensis]
MRKAYVSVSGVKAGILEELQGGKYQFTYFDDYHGAPISLTMPLTKKVYDFAEFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT120929 NZ_CP038273:c2630778-2630470 [Legionella israelensis]
ATGAGAAAAGCATATGTATCAGTGAGTGGTGTTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
CTACTTTGATGATTATCACGGTGCACCTATTTCTCTCACAATGCCTTTAACAAAAAAGGTCTATGATTTTGCTGAGTTCC
CCCCCTTTTTTGAAGGCTTACTTCCAGAAGGCATTATGCTTGAAGCACTATTACGCAAATATAAGATAGATAAAAATGAC
TATTTTGGCCAATTGATAATTGTTGGCCAAGATGTCGTAGGAGCAGTTACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0W516

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0W527

References