Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2596848..2598088 Replicon chromosome
Accession NZ_CP038271
Organism Legionella geestiana strain 1308

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W0TPD4
Locus tag E4T54_RS11590 Protein ID WP_028387131.1
Coordinates 2597153..2598088 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W0TPD9
Locus tag E4T54_RS11585 Protein ID WP_028387130.1
Coordinates 2596848..2597156 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4T54_RS11565 2592380..2594068 + 1689 WP_028387126.1 SGNH/GDSL hydrolase family protein -
E4T54_RS11570 2594163..2595752 + 1590 WP_028387127.1 peptide chain release factor 3 -
E4T54_RS11575 2595793..2596179 - 387 WP_028387128.1 hypothetical protein -
E4T54_RS11580 2596624..2596851 + 228 WP_028387129.1 helix-turn-helix transcriptional regulator -
E4T54_RS11585 2596848..2597156 + 309 WP_028387130.1 HipA N-terminal domain-containing protein Antitoxin
E4T54_RS11590 2597153..2598088 + 936 WP_028387131.1 HipA domain-containing protein Toxin
E4T54_RS11595 2598111..2599526 - 1416 WP_028387132.1 NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta -
E4T54_RS11600 2599523..2599831 - 309 WP_028387133.1 NAD(P) transhydrogenase subunit alpha -
E4T54_RS11605 2599824..2600948 - 1125 WP_028387134.1 NAD(P) transhydrogenase subunit alpha -
E4T54_RS11610 2601036..2602418 - 1383 WP_028387135.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-274)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35709.42 Da        Isoelectric Point: 8.7955

>T120927 WP_028387131.1 NZ_CP038271:2597153-2598088 [Legionella geestiana]
MKHCPVTYEAISEEEVYSQRGLHLLSPRLKTLNPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKTKEGCFEIVDQNG
HYILKPQSDSYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSMTYFIKRFDREGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIESVKLLKLTLFNFLVGNEDMHLKNFSLITRDRKICLSPAYDLLNSTIAQKNTKEELALPLKG
KKNHLTKKDLLNYFAIEKLGLNQNVIDGIVQEIRLATPVWRELIGRSFLSRPMQESYLELLEERCRRLNIL

Download         Length: 936 bp

>T120927 NZ_CP038271:2597153-2598088 [Legionella geestiana]
ATGAAACACTGTCCTGTTACCTATGAAGCGATTAGTGAGGAGGAAGTGTATTCGCAGCGTGGATTACATTTGCTGTCCCC
CCGGTTAAAAACCCTTAACCCGTTAGATTTAAGTGCCGATGAGCAGCGGCAGGAAGCAATTGCCAGGGTTGGAAAGATGT
CTGTTCAAGGTGTACAGAAGAAATTAAGTGCAAAACTCAAGACTAAAGAGGGTTGTTTTGAAATTGTCGATCAAAACGGT
CATTACATTTTAAAACCGCAAAGCGACAGTTACCCGGAATTACCGGAAAATGAAGCCATTACCATGACACTTGCCAAAAC
CATTGGCCTTGAAGTGCCGGTTCATGGTCTTGTGTATTCCAAAGACAACAGCATGACCTACTTTATAAAACGCTTTGACA
GAGAGGGTCATAACAAAAAACTGGCACTGGAAGATTTTGCACAGTTGTCGGGTGAAGACAGGCACACTAAATATAAAAGT
TCCATGGAAAAAGTGATTGCCGTCATAGAGCAGTTTTGTACATTCCCCAAAATTGAATCCGTTAAATTATTAAAGTTGAC
ACTGTTTAATTTTTTGGTCGGCAACGAAGACATGCATCTTAAAAATTTCTCCTTAATTACCCGGGACAGAAAAATTTGCC
TCTCTCCTGCATATGATTTACTGAATTCAACAATCGCTCAAAAAAATACCAAAGAAGAGCTTGCTCTGCCTTTAAAAGGT
AAAAAGAACCATCTAACAAAGAAAGATTTGCTTAACTATTTTGCCATTGAAAAATTAGGACTCAATCAAAACGTCATTGA
TGGAATCGTACAGGAAATTCGTCTCGCCACACCCGTATGGCGAGAGCTCATTGGCCGCAGTTTTTTATCTCGACCAATGC
AGGAGAGCTATCTCGAGTTGCTGGAGGAAAGATGCAGGCGATTAAACATCCTGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11501.31 Da        Isoelectric Point: 4.5859

>AT120927 WP_028387130.1 NZ_CP038271:2596848-2597156 [Legionella geestiana]
MRTAMVAVNGINAGILEELPDGKYQFIYLDDYHGAPVSLTMPLTKKNYVFDRFPPFFEGLLPEGMMLEALLRKNKIDKND
YFSQLTAVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT120927 NZ_CP038271:2596848-2597156 [Legionella geestiana]
ATGAGAACAGCGATGGTAGCAGTCAACGGAATTAACGCTGGAATATTAGAAGAACTTCCGGATGGAAAATATCAATTTAT
TTATCTCGATGATTATCATGGAGCGCCCGTTTCTCTGACTATGCCTCTGACAAAAAAGAACTATGTATTTGATCGATTTC
CGCCATTTTTTGAAGGACTGTTGCCCGAGGGCATGATGCTTGAAGCACTGCTGCGCAAAAATAAAATTGATAAAAATGAT
TATTTTAGTCAGTTAACGGCTGTTGGACAGGATGTCGTAGGTGCCGTGACTATCGAGGAACTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0TPD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0TPD9

References