Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2475718..2475902 Replicon chromosome
Accession NZ_CP038270
Organism Staphylococcus aureus strain O408 isolate B115

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SaO408_RS12760 Protein ID WP_000482647.1
Coordinates 2475795..2475902 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2475718..2475778 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO408_RS12735 2471172..2471339 - 168 WP_031901225.1 hypothetical protein -
SaO408_RS12745 2471570..2473303 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
SaO408_RS12750 2473328..2475091 - 1764 WP_001064824.1 ABC transporter ATP-binding protein/permease -
- 2475718..2475778 + 61 - - Antitoxin
SaO408_RS12760 2475795..2475902 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SaO408_RS12765 2476036..2476422 - 387 WP_000779350.1 flippase GtxA -
SaO408_RS12770 2476690..2477832 + 1143 WP_001176867.1 glycerate kinase -
SaO408_RS12775 2477892..2478551 + 660 WP_000831298.1 membrane protein -
SaO408_RS12780 2478734..2479945 + 1212 WP_001191927.1 multidrug effflux MFS transporter -
SaO408_RS12785 2480068..2480541 - 474 WP_000456488.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T120922 WP_000482647.1 NZ_CP038270:c2475902-2475795 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T120922 NZ_CP038270:c2475902-2475795 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT120922 NZ_CP038270:2475718-2475778 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References