Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2458342..2458859 Replicon chromosome
Accession NZ_CP038268
Organism Staphylococcus aureus strain O55 isolate B118

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag SaO55_RS12775 Protein ID WP_000113260.1
Coordinates 2458342..2458608 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SaO55_RS12780 Protein ID WP_000584499.1
Coordinates 2458608..2458859 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO55_RS12745 2453438..2453974 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SaO55_RS12755 2454552..2455376 - 825 WP_000594633.1 formate/nitrite transporter family protein -
SaO55_RS12760 2455579..2455761 - 183 WP_000079140.1 hypothetical protein -
SaO55_RS12765 2455848..2456315 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SaO55_RS12770 2456501..2458048 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SaO55_RS12775 2458342..2458608 - 267 WP_000113260.1 Txe/YoeB family addiction module toxin Toxin
SaO55_RS12780 2458608..2458859 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SaO55_RS12785 2459024..2459125 - 102 Protein_2371 hypothetical protein -
SaO55_RS12790 2459132..2459731 - 600 WP_000162810.1 DsbA family protein -
SaO55_RS12795 2459750..2460112 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SaO55_RS12800 2460367..2461617 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
SaO55_RS12805 2461714..2462445 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SaO55_RS12810 2462442..2463161 - 720 WP_000479579.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.99 Da        Isoelectric Point: 10.0373

>T120899 WP_000113260.1 NZ_CP038268:c2458608-2458342 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T120899 NZ_CP038268:c2458608-2458342 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAGATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT120899 WP_000584499.1 NZ_CP038268:c2458859-2458608 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT120899 NZ_CP038268:c2458859-2458608 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References