Detailed information of TA system TA120891

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF2/-
• Location: 354956..355474
• Replicon: chromosome
• Accession: NZ_CP038268
• Organism: Staphylococcus aureus strain O55 isolate B118

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: SaO55_RS01705
• Protein ID: WP_000448764.1
• Coordinates: 355172..355474 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	354956..355092 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO55_RS01665	350050..350340	+	291	WP_000179860.1	hypothetical protein	-
SaO55_RS01670	350356..352266	+	1911	WP_000429563.1	hypothetical protein	-
SaO55_RS01675	352266..353732	+	1467	WP_000067157.1	BppU family phage baseplate upper protein	-
SaO55_RS01680	353732..354121	+	390	WP_001166604.1	DUF2977 domain-containing protein	-
SaO55_RS01685	354114..354278	+	165	WP_000916020.1	XkdX family protein	-
SaO55_RS01690	354324..354623	+	300	WP_000466773.1	DUF2951 family protein	-
SaO55_RS14505	354775..354964	+	190	Protein_321	putative holin-like toxin	-
-	354956..355092	-	137	NuclAT_0	-	Antitoxin
-	354956..355092	-	137	NuclAT_0	-	Antitoxin
-	354956..355092	-	137	NuclAT_0	-	Antitoxin
-	354956..355092	-	137	NuclAT_0	-	Antitoxin
SaO55_RS01700	355011..355121	-	111	WP_070003492.1	hypothetical protein	-
SaO55_RS01705	355172..355474	+	303	WP_000448764.1	phage holin	Toxin
SaO55_RS01710	355486..356940	+	1455	WP_000930277.1	N-acetylmuramoyl-L-alanine amidase	-
SaO55_RS01720	358454..358951	+	498	WP_001803960.1	hypothetical protein	-
SaO55_RS01730	359511..360338	-	828	WP_000136028.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	312837..356940	44103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (3-68)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11230.99 Da
• Isoelectric Point: 9.6587

>T120891 WP_000448764.1 NZ_CP038268:355172-355474 [Staphylococcus aureus]
METKVITRYIVLILALVNQFLANKGISPIPVDEESISSIILTVIALYTAYKDNPTSQEGRWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T120891 NZ_CP038268:355172-355474 [Staphylococcus aureus]
ATGGAAACAAAAGTAATAACAAGATATATTGTATTAATTTTAGCGTTAGTCAATCAGTTTTTAGCGAACAAAGGTATAAG
CCCGATACCAGTAGATGAAGAGAGTATTTCATCGATTATCTTAACAGTCATTGCTTTATACACCGCTTATAAAGACAATC
CAACATCACAAGAAGGACGCTGGGCGAATCAAAAACTAAAGAAATATAAAGCTGAAAATAAGTATAGAAAAGCAACAGGA
CAAGCGCCAATTAAAGAAGTAATGACACCTACAAATATGAATGACACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 137 bp

>AT120891 NZ_CP038268:c355092-354956 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGGAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGACCTCTGTAGTTAAAT
GAATTTATATAATCCTCTAACCATCGTACTCGTCAAAGTTAGCGATGGTTATTTTTT

Structures

Antitoxin