Detailed information of TA system TA120890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 325112..325526
• Replicon: chromosome
• Accession: NZ_CP038268
• Organism: Staphylococcus aureus strain O55 isolate B118

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: SaO55_RS01520
• Protein ID: WP_001065074.1
• Coordinates: 325112..325363 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SaO55_RS14445
• Protein ID: WP_000028424.1
• Coordinates: 325353..325526 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO55_RS01475	320722..322674	+	1953	WP_078103306.1	DNA polymerase	-
SaO55_RS01480	322687..322872	+	186	WP_001164629.1	DUF3113 family protein	-
SaO55_RS01485	322872..323273	+	402	WP_000113977.1	PVL family protein	-
SaO55_RS01490	323273..323527	+	255	WP_031915842.1	DUF3310 domain-containing protein	-
SaO55_RS01495	323527..323775	+	249	WP_135789263.1	hypothetical protein	-
SaO55_RS01500	323788..324213	+	426	WP_044122121.1	hypothetical protein	-
SaO55_RS01505	324210..324404	+	195	WP_000983952.1	hypothetical protein	-
SaO55_RS01510	324401..324838	+	438	WP_044122119.1	hypothetical protein	-
SaO55_RS01515	324835..325119	+	285	WP_001105603.1	hypothetical protein	-
SaO55_RS01520	325112..325363	+	252	WP_001065074.1	DUF1024 family protein	Toxin
SaO55_RS14445	325353..325526	+	174	WP_000028424.1	hypothetical protein	Antitoxin
SaO55_RS01525	325527..325808	+	282	WP_000454994.1	hypothetical protein	-
SaO55_RS14450	325809..325970	+	162	WP_000889682.1	hypothetical protein	-
SaO55_RS01530	325985..326518	+	534	Protein_288	dUTPase	-
SaO55_RS01535	326555..326800	+	246	WP_001282074.1	hypothetical protein	-
SaO55_RS01540	326797..327003	+	207	WP_031794884.1	DUF1381 domain-containing protein	-
SaO55_RS01545	327000..327152	+	153	WP_000595260.1	transcriptional activator RinB	-
SaO55_RS01550	327220..327420	+	201	WP_115207349.1	DUF1514 family protein	-
SaO55_RS01555	327469..329916	+	2448	WP_135789119.1	virulence-associated E family protein	-
SaO55_RS01560	330025..330123	-	99	WP_001801650.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	312837..356940	44103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9513.41 Da
• Isoelectric Point: 3.7128

>T120890 WP_001065074.1 NZ_CP038268:325112-325363 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T120890 NZ_CP038268:325112-325363 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT120890 WP_000028424.1 NZ_CP038268:325353-325526 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT120890 NZ_CP038268:325353-325526 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA