Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 325112..325526 Replicon chromosome
Accession NZ_CP038268
Organism Staphylococcus aureus strain O55 isolate B118

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SaO55_RS01520 Protein ID WP_001065074.1
Coordinates 325112..325363 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SaO55_RS14445 Protein ID WP_000028424.1
Coordinates 325353..325526 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SaO55_RS01475 320722..322674 + 1953 WP_078103306.1 DNA polymerase -
SaO55_RS01480 322687..322872 + 186 WP_001164629.1 DUF3113 family protein -
SaO55_RS01485 322872..323273 + 402 WP_000113977.1 PVL family protein -
SaO55_RS01490 323273..323527 + 255 WP_031915842.1 DUF3310 domain-containing protein -
SaO55_RS01495 323527..323775 + 249 WP_135789263.1 hypothetical protein -
SaO55_RS01500 323788..324213 + 426 WP_044122121.1 hypothetical protein -
SaO55_RS01505 324210..324404 + 195 WP_000983952.1 hypothetical protein -
SaO55_RS01510 324401..324838 + 438 WP_044122119.1 hypothetical protein -
SaO55_RS01515 324835..325119 + 285 WP_001105603.1 hypothetical protein -
SaO55_RS01520 325112..325363 + 252 WP_001065074.1 DUF1024 family protein Toxin
SaO55_RS14445 325353..325526 + 174 WP_000028424.1 hypothetical protein Antitoxin
SaO55_RS01525 325527..325808 + 282 WP_000454994.1 hypothetical protein -
SaO55_RS14450 325809..325970 + 162 WP_000889682.1 hypothetical protein -
SaO55_RS01530 325985..326518 + 534 Protein_288 dUTPase -
SaO55_RS01535 326555..326800 + 246 WP_001282074.1 hypothetical protein -
SaO55_RS01540 326797..327003 + 207 WP_031794884.1 DUF1381 domain-containing protein -
SaO55_RS01545 327000..327152 + 153 WP_000595260.1 transcriptional activator RinB -
SaO55_RS01550 327220..327420 + 201 WP_115207349.1 DUF1514 family protein -
SaO55_RS01555 327469..329916 + 2448 WP_135789119.1 virulence-associated E family protein -
SaO55_RS01560 330025..330123 - 99 WP_001801650.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 312837..356940 44103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9513.41 Da        Isoelectric Point: 3.7128

>T120890 WP_001065074.1 NZ_CP038268:325112-325363 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T120890 NZ_CP038268:325112-325363 [Staphylococcus aureus]
ATGAATAACCGTGAACAAATAGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT120890 WP_000028424.1 NZ_CP038268:325353-325526 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT120890 NZ_CP038268:325353-325526 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References