Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 12371..13029 Replicon plasmid pEC_gr6
Accession NZ_CP038264
Organism Acinetobacter baumannii strain LEV1449/17Ec

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4K03_RS18875 Protein ID WP_000312250.1
Coordinates 12670..13029 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4K03_RS18870 Protein ID WP_001096429.1
Coordinates 12371..12670 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K03_RS18845 8110..10113 - 2004 WP_033854405.1 type I restriction-modification system subunit M -
E4K03_RS18850 10282..10947 + 666 WP_135013698.1 hypothetical protein -
E4K03_RS18855 11090..11530 + 441 Protein_9 hypothetical protein -
E4K03_RS18860 11506..11685 + 180 WP_033854395.1 hypothetical protein -
E4K03_RS18870 12371..12670 - 300 WP_001096429.1 helix-turn-helix transcriptional regulator Antitoxin
E4K03_RS18875 12670..13029 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4K03_RS18880 13230..13796 + 567 WP_000710385.1 hypothetical protein -
E4K03_RS18885 13845..14027 + 183 WP_000373385.1 hypothetical protein -
E4K03_RS18890 14094..14792 + 699 WP_033854396.1 hypothetical protein -
E4K03_RS18895 14931..15314 + 384 WP_000654348.1 hypothetical protein -
E4K03_RS18900 15381..16139 + 759 WP_033854397.1 hypothetical protein -
E4K03_RS18905 16191..16526 + 336 WP_038337724.1 hypothetical protein -
E4K03_RS18915 17393..17707 + 315 WP_000708713.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..76956 76956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T120887 WP_000312250.1 NZ_CP038264:c13029-12670 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T120887 NZ_CP038264:c13029-12670 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT120887 WP_001096429.1 NZ_CP038264:c12670-12371 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT120887 NZ_CP038264:c12670-12371 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References