Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 19519..20104 Replicon plasmid pEH_gr3
Accession NZ_CP038260
Organism Acinetobacter baumannii strain 39741

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag E4K02_RS19335 Protein ID WP_000897309.1
Coordinates 19784..20104 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A009MRQ1
Locus tag E4K02_RS19330 Protein ID WP_032001914.1
Coordinates 19519..19791 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4K02_RS19315 15278..16570 - 1293 WP_004706945.1 MFS transporter -
E4K02_RS19320 16625..17863 - 1239 WP_004706948.1 M24 family metallopeptidase -
E4K02_RS19325 17979..18938 - 960 WP_004706950.1 GlxA family transcriptional regulator -
E4K02_RS19330 19519..19791 - 273 WP_032001914.1 helix-turn-helix domain-containing protein Antitoxin
E4K02_RS19335 19784..20104 - 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4K02_RS19340 20291..20488 - 198 WP_000476222.1 hypothetical protein -
E4K02_RS19345 20555..20782 - 228 WP_000921865.1 hypothetical protein -
E4K02_RS19350 20880..21095 - 216 WP_000071892.1 cold-shock protein -
E4K02_RS19355 21226..21972 + 747 WP_002122556.1 IS5-like element ISAba31 family transposase -
E4K02_RS19360 22340..22951 - 612 WP_008942536.1 recombinase family protein -
E4K02_RS19365 23132..23659 - 528 WP_000537572.1 plasmid pRiA4b ORF-3 family protein -
E4K02_RS19370 23732..23923 - 192 WP_000102616.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25856 25856
- flank IS/Tn - - 21226..21972 746


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T120880 WP_000897309.1 NZ_CP038260:c20104-19784 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T120880 NZ_CP038260:c20104-19784 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10088.61 Da        Isoelectric Point: 8.6582

>AT120880 WP_032001914.1 NZ_CP038260:c19791-19519 [Acinetobacter baumannii]
MDNNLLDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT120880 NZ_CP038260:c19791-19519 [Acinetobacter baumannii]
ATGGATAACAACTTATTAGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A009MRQ1

References