Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 2303315..2303919 | Replicon | chromosome |
Accession | NZ_CP038254 | ||
Organism | Legionella israelensis strain HL-0427-4011 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | E3983_RS10325 | Protein ID | WP_135060908.1 |
Coordinates | 2303608..2303919 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | E3983_RS10320 | Protein ID | WP_135060907.1 |
Coordinates | 2303315..2303605 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E3983_RS10275 | 2298366..2298773 | + | 408 | WP_209025833.1 | hypothetical protein | - |
E3983_RS10280 | 2298791..2299039 | - | 249 | WP_135060902.1 | helix-turn-helix domain-containing protein | - |
E3983_RS10285 | 2299203..2299526 | + | 324 | WP_135060903.1 | hypothetical protein | - |
E3983_RS10290 | 2299665..2299946 | - | 282 | WP_209025834.1 | hypothetical protein | - |
E3983_RS10305 | 2301145..2301570 | - | 426 | WP_135060904.1 | hypothetical protein | - |
E3983_RS10310 | 2301510..2302169 | - | 660 | WP_135060905.1 | hypothetical protein | - |
E3983_RS10315 | 2302361..2302777 | - | 417 | WP_135060906.1 | transposase | - |
E3983_RS10320 | 2303315..2303605 | - | 291 | WP_135060907.1 | helix-turn-helix domain-containing protein | Antitoxin |
E3983_RS10325 | 2303608..2303919 | - | 312 | WP_135060908.1 | hypothetical protein | Toxin |
E3983_RS10330 | 2305124..2305330 | - | 207 | Protein_2033 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
E3983_RS10335 | 2305547..2306491 | - | 945 | Protein_2034 | DUF927 domain-containing protein | - |
E3983_RS10340 | 2306567..2306839 | - | 273 | WP_135060909.1 | helix-turn-helix domain-containing protein | - |
E3983_RS10345 | 2307185..2307529 | + | 345 | WP_082636534.1 | DUF1778 domain-containing protein | - |
E3983_RS10350 | 2307526..2308023 | + | 498 | WP_058501954.1 | GNAT family N-acetyltransferase | - |
E3983_RS10355 | 2308411..2308743 | + | 333 | WP_135060910.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12061.99 Da Isoelectric Point: 9.6229
>T120870 WP_135060908.1 NZ_CP038254:c2303919-2303608 [Legionella israelensis]
MIFIETPIFTEDVQVLLSDKEYADFQQYLAENPMAGDVIQQTGGLRKIRWSAKGKGKRGGVRIIYYYVMPDSQIRLLLIY
QKGIQDNLTAEQKKILRHINERW
MIFIETPIFTEDVQVLLSDKEYADFQQYLAENPMAGDVIQQTGGLRKIRWSAKGKGKRGGVRIIYYYVMPDSQIRLLLIY
QKGIQDNLTAEQKKILRHINERW
Download Length: 312 bp
>T120870 NZ_CP038254:c2303919-2303608 [Legionella israelensis]
ATGATTTTTATAGAGACTCCAATTTTTACGGAGGATGTACAAGTTTTATTATCTGATAAGGAGTATGCTGATTTTCAACA
ATATCTGGCTGAAAATCCTATGGCAGGTGATGTGATTCAGCAAACTGGAGGATTAAGAAAAATACGTTGGTCAGCAAAAG
GAAAGGGCAAGCGAGGTGGTGTACGAATTATCTACTATTATGTAATGCCTGATTCCCAGATAAGATTATTACTGATTTAC
CAAAAAGGTATACAAGATAATTTGACAGCTGAACAAAAGAAGATTTTAAGACATATTAATGAGCGGTGGTGA
ATGATTTTTATAGAGACTCCAATTTTTACGGAGGATGTACAAGTTTTATTATCTGATAAGGAGTATGCTGATTTTCAACA
ATATCTGGCTGAAAATCCTATGGCAGGTGATGTGATTCAGCAAACTGGAGGATTAAGAAAAATACGTTGGTCAGCAAAAG
GAAAGGGCAAGCGAGGTGGTGTACGAATTATCTACTATTATGTAATGCCTGATTCCCAGATAAGATTATTACTGATTTAC
CAAAAAGGTATACAAGATAATTTGACAGCTGAACAAAAGAAGATTTTAAGACATATTAATGAGCGGTGGTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10980.71 Da Isoelectric Point: 10.3067
>AT120870 WP_135060907.1 NZ_CP038254:c2303605-2303315 [Legionella israelensis]
MDTKLFERLVESMNQMNEIVEGERNPSREFVVDALHVKEIRKKTGLTQAKFSKLIDVRLGTLRNWEQGRREPTGPARALL
KAISNDPEHVLIALAK
MDTKLFERLVESMNQMNEIVEGERNPSREFVVDALHVKEIRKKTGLTQAKFSKLIDVRLGTLRNWEQGRREPTGPARALL
KAISNDPEHVLIALAK
Download Length: 291 bp
>AT120870 NZ_CP038254:c2303605-2303315 [Legionella israelensis]
ATGGATACGAAATTATTTGAAAGACTCGTAGAAAGCATGAACCAAATGAATGAGATTGTCGAAGGTGAACGAAATCCATC
ACGTGAATTTGTTGTTGATGCATTGCATGTGAAAGAAATTAGAAAAAAGACTGGCCTAACGCAAGCCAAATTTTCAAAAC
TAATTGACGTTAGGTTGGGAACATTAAGAAATTGGGAGCAGGGGCGCAGGGAACCGACAGGTCCTGCCAGGGCGCTTCTT
AAAGCGATATCAAATGATCCTGAACATGTATTAATTGCATTGGCGAAATGA
ATGGATACGAAATTATTTGAAAGACTCGTAGAAAGCATGAACCAAATGAATGAGATTGTCGAAGGTGAACGAAATCCATC
ACGTGAATTTGTTGTTGATGCATTGCATGTGAAAGAAATTAGAAAAAAGACTGGCCTAACGCAAGCCAAATTTTCAAAAC
TAATTGACGTTAGGTTGGGAACATTAAGAAATTGGGAGCAGGGGCGCAGGGAACCGACAGGTCCTGCCAGGGCGCTTCTT
AAAGCGATATCAAATGATCCTGAACATGTATTAATTGCATTGGCGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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