Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2303315..2303919 Replicon chromosome
Accession NZ_CP038254
Organism Legionella israelensis strain HL-0427-4011

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3983_RS10325 Protein ID WP_135060908.1
Coordinates 2303608..2303919 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E3983_RS10320 Protein ID WP_135060907.1
Coordinates 2303315..2303605 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3983_RS10275 2298366..2298773 + 408 WP_209025833.1 hypothetical protein -
E3983_RS10280 2298791..2299039 - 249 WP_135060902.1 helix-turn-helix domain-containing protein -
E3983_RS10285 2299203..2299526 + 324 WP_135060903.1 hypothetical protein -
E3983_RS10290 2299665..2299946 - 282 WP_209025834.1 hypothetical protein -
E3983_RS10305 2301145..2301570 - 426 WP_135060904.1 hypothetical protein -
E3983_RS10310 2301510..2302169 - 660 WP_135060905.1 hypothetical protein -
E3983_RS10315 2302361..2302777 - 417 WP_135060906.1 transposase -
E3983_RS10320 2303315..2303605 - 291 WP_135060907.1 helix-turn-helix domain-containing protein Antitoxin
E3983_RS10325 2303608..2303919 - 312 WP_135060908.1 hypothetical protein Toxin
E3983_RS10330 2305124..2305330 - 207 Protein_2033 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
E3983_RS10335 2305547..2306491 - 945 Protein_2034 DUF927 domain-containing protein -
E3983_RS10340 2306567..2306839 - 273 WP_135060909.1 helix-turn-helix domain-containing protein -
E3983_RS10345 2307185..2307529 + 345 WP_082636534.1 DUF1778 domain-containing protein -
E3983_RS10350 2307526..2308023 + 498 WP_058501954.1 GNAT family N-acetyltransferase -
E3983_RS10355 2308411..2308743 + 333 WP_135060910.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-73)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12061.99 Da        Isoelectric Point: 9.6229

>T120870 WP_135060908.1 NZ_CP038254:c2303919-2303608 [Legionella israelensis]
MIFIETPIFTEDVQVLLSDKEYADFQQYLAENPMAGDVIQQTGGLRKIRWSAKGKGKRGGVRIIYYYVMPDSQIRLLLIY
QKGIQDNLTAEQKKILRHINERW

Download         Length: 312 bp

>T120870 NZ_CP038254:c2303919-2303608 [Legionella israelensis]
ATGATTTTTATAGAGACTCCAATTTTTACGGAGGATGTACAAGTTTTATTATCTGATAAGGAGTATGCTGATTTTCAACA
ATATCTGGCTGAAAATCCTATGGCAGGTGATGTGATTCAGCAAACTGGAGGATTAAGAAAAATACGTTGGTCAGCAAAAG
GAAAGGGCAAGCGAGGTGGTGTACGAATTATCTACTATTATGTAATGCCTGATTCCCAGATAAGATTATTACTGATTTAC
CAAAAAGGTATACAAGATAATTTGACAGCTGAACAAAAGAAGATTTTAAGACATATTAATGAGCGGTGGTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10980.71 Da        Isoelectric Point: 10.3067

>AT120870 WP_135060907.1 NZ_CP038254:c2303605-2303315 [Legionella israelensis]
MDTKLFERLVESMNQMNEIVEGERNPSREFVVDALHVKEIRKKTGLTQAKFSKLIDVRLGTLRNWEQGRREPTGPARALL
KAISNDPEHVLIALAK

Download         Length: 291 bp

>AT120870 NZ_CP038254:c2303605-2303315 [Legionella israelensis]
ATGGATACGAAATTATTTGAAAGACTCGTAGAAAGCATGAACCAAATGAATGAGATTGTCGAAGGTGAACGAAATCCATC
ACGTGAATTTGTTGTTGATGCATTGCATGTGAAAGAAATTAGAAAAAAGACTGGCCTAACGCAAGCCAAATTTTCAAAAC
TAATTGACGTTAGGTTGGGAACATTAAGAAATTGGGAGCAGGGGCGCAGGGAACCGACAGGTCCTGCCAGGGCGCTTCTT
AAAGCGATATCAAATGATCCTGAACATGTATTAATTGCATTGGCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References