120865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1628449..1628961 Replicon chromosome
Accession NZ_CP038253
Organism Streptococcus pneumoniae strain TVO_1901929

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag ES298_RS08200 Protein ID WP_000924721.1
Coordinates 1628449..1628703 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag ES298_RS08205 Protein ID WP_000388572.1
Coordinates 1628707..1628961 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES298_RS08185 (ES298_08630) 1625550..1625864 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
ES298_RS08190 (ES298_08635) 1625889..1626515 - 627 WP_000775037.1 guanylate kinase -
ES298_RS08195 (ES298_08640) 1626645..1628258 - 1614 WP_000404929.1 ribonuclease Y -
ES298_RS08200 (ES298_08645) 1628449..1628703 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
ES298_RS08205 (ES298_08650) 1628707..1628961 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ES298_RS08210 (ES298_08655) 1629199..1630296 - 1098 WP_000156323.1 nucleotidyltransferase -
ES298_RS08215 (ES298_08660) 1630320..1632131 - 1812 WP_001025033.1 NACHT domain-containing protein -
ES298_RS08220 (ES298_08665) 1632172..1632912 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
ES298_RS08225 (ES298_08670) 1633232..1633585 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T120865 WP_000924721.1 NZ_CP038253:c1628703-1628449 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T120865 NZ_CP038253:c1628703-1628449 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT120865 WP_000388572.1 NZ_CP038253:c1628961-1628707 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT120865 NZ_CP038253:c1628961-1628707 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References