120847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 70278..70797 Replicon chromosome
Accession NZ_CP038242
Organism Staphylococcus warneri strain GD01

Toxin (Protein)


Gene name yoeB Uniprot ID A0A364USX6
Locus tag EOJ31_RS00305 Protein ID WP_002466416.1
Coordinates 70525..70797 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2T4PYE3
Locus tag EOJ31_RS00300 Protein ID WP_002466398.1
Coordinates 70278..70532 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOJ31_RS00285 65795..67117 + 1323 WP_002466404.1 PrsW family intramembrane metalloprotease -
EOJ31_RS00290 67268..67705 + 438 WP_002466379.1 hypothetical protein -
EOJ31_RS00295 67832..70033 - 2202 WP_189723475.1 YSIRK-type signal peptide-containing protein -
EOJ31_RS00300 70278..70532 + 255 WP_002466398.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EOJ31_RS00305 70525..70797 + 273 WP_002466416.1 Txe/YoeB family addiction module toxin Toxin
EOJ31_RS00310 71190..72560 + 1371 WP_189723477.1 citrate:proton symporter -
EOJ31_RS00315 72653..73291 - 639 WP_002466369.1 NAD(P)H-dependent oxidoreductase -
EOJ31_RS00320 73578..75008 + 1431 WP_002466385.1 multidrug efflux MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 91 a.a.        Molecular weight: 10852.63 Da        Isoelectric Point: 9.9029

>T120847 WP_002466416.1 NZ_CP038242:70525-70797 [Staphylococcus warneri]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINQLIKCINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYHYFK

Download         Length: 273 bp

>T120847 NZ_CP038242:70525-70797 [Staphylococcus warneri]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCAATTGATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAAGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATAATT
ATTGTTTCTTGTAAATATCATTATTTTAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9345.27 Da        Isoelectric Point: 4.0334

>AT120847 WP_002466398.1 NZ_CP038242:70278-70532 [Staphylococcus warneri]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIEVDL
ESYE

Download         Length: 255 bp

>AT120847 NZ_CP038242:70278-70532 [Staphylococcus warneri]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAATGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTACTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCCCAACACTTGGCTAAATCTATAGAAGATGCTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A364USX6


Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PYE3

References