Detailed information of TA system TA120841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2459551..2460074
• Replicon: chromosome
• Accession: NZ_CP038229
• Organism: Staphylococcus aureus strain MJ163

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E4J95_RS12120
• Protein ID: WP_045177693.1
• Coordinates: 2459551..2459817 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: E4J95_RS12125
• Protein ID: WP_000587618.1
• Coordinates: 2459817..2460074 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4J95_RS12100	2454857..2456044	-	1188	WP_045177690.1	MFS transporter	-
E4J95_RS12105	2456440..2457216	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
E4J95_RS12110	2457209..2457871	-	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
E4J95_RS12115	2458119..2459195	-	1077	WP_001076673.1	M42 family metallopeptidase	-
E4J95_RS12120	2459551..2459817	-	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
E4J95_RS12125	2459817..2460074	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E4J95_RS12130	2460434..2460889	+	456	WP_000732090.1	YehR family lipoprotein	-
E4J95_RS12135	2461057..2462634	-	1578	WP_169449300.1	FMN-binding glutamate synthase family protein	-
E4J95_RS12140	2462829..2463578	+	750	WP_000072443.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T120841 WP_045177693.1 NZ_CP038229:c2459817-2459551 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T120841 NZ_CP038229:c2459817-2459551 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT120841 WP_000587618.1 NZ_CP038229:c2460074-2459817 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT120841 NZ_CP038229:c2460074-2459817 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2