120838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2403009..2403526 Replicon chromosome
Accession NZ_CP038229
Organism Staphylococcus aureus strain MJ163

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E4J95_RS11845 Protein ID WP_000113262.1
Coordinates 2403009..2403275 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E4J95_RS11850 Protein ID WP_000584499.1
Coordinates 2403275..2403526 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4J95_RS11820 2398436..2398972 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
E4J95_RS11825 2399205..2400029 - 825 WP_045177662.1 formate/nitrite transporter family protein -
E4J95_RS11830 2400246..2400428 - 183 WP_000230294.1 hypothetical protein -
E4J95_RS11835 2400512..2400979 - 468 WP_000153346.1 SRPBCC domain-containing protein -
E4J95_RS11840 2401165..2402715 - 1551 WP_045177665.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E4J95_RS11845 2403009..2403275 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E4J95_RS11850 2403275..2403526 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E4J95_RS11855 2403691..2403792 - 102 WP_001791744.1 hypothetical protein -
E4J95_RS11860 2403799..2404398 - 600 WP_000162812.1 DsbA family protein -
E4J95_RS11865 2404417..2404779 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E4J95_RS11870 2405034..2406284 + 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
E4J95_RS11875 2406381..2407112 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
E4J95_RS11880 2407109..2407828 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T120838 WP_000113262.1 NZ_CP038229:c2403275-2403009 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T120838 NZ_CP038229:c2403275-2403009 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT120838 WP_000584499.1 NZ_CP038229:c2403526-2403275 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT120838 NZ_CP038229:c2403526-2403275 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References