Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2148582..2148844 Replicon chromosome
Accession NZ_CP038229
Organism Staphylococcus aureus strain MJ163

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag E4J95_RS10520 Protein ID WP_001802298.1
Coordinates 2148740..2148844 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2148582..2148745 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4J95_RS10500 2144765..2145430 - 666 WP_045177733.1 SDR family oxidoreductase -
E4J95_RS10505 2145582..2145902 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
E4J95_RS10510 2145904..2146884 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
E4J95_RS10515 2147150..2148241 + 1092 WP_045177732.1 lytic regulatory protein -
- 2148582..2148745 + 164 - - Antitoxin
E4J95_RS10520 2148740..2148844 - 105 WP_001802298.1 hypothetical protein Toxin
E4J95_RS10525 2149524..2149682 + 159 WP_001792784.1 hypothetical protein -
E4J95_RS10530 2150341..2151198 - 858 WP_045177730.1 Cof-type HAD-IIB family hydrolase -
E4J95_RS10535 2151265..2152047 - 783 WP_045177727.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T120837 WP_001802298.1 NZ_CP038229:c2148844-2148740 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T120837 NZ_CP038229:c2148844-2148740 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT120837 NZ_CP038229:2148582-2148745 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References