Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2503431..2503954 Replicon chromosome
Accession NZ_CP038183
Organism Staphylococcus aureus strain MJ015

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag E3306_RS12460 Protein ID WP_000074045.1
Coordinates 2503431..2503697 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag E3306_RS12465 Protein ID WP_000587619.1
Coordinates 2503697..2503954 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3306_RS12440 2498738..2499925 - 1188 WP_000026194.1 MFS transporter -
E3306_RS12445 2500321..2501097 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E3306_RS12450 2501090..2501752 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
E3306_RS12455 2502000..2503076 - 1077 WP_001076671.1 M42 family metallopeptidase -
E3306_RS12460 2503431..2503697 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
E3306_RS12465 2503697..2503954 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3306_RS12470 2504314..2504769 + 456 WP_000732079.1 DUF1307 domain-containing protein -
E3306_RS12475 2504937..2506514 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
E3306_RS12480 2506710..2507459 + 750 WP_000072465.1 hypothetical protein -
E3306_RS12485 2507683..2508876 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T120790 WP_000074045.1 NZ_CP038183:c2503697-2503431 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T120790 NZ_CP038183:c2503697-2503431 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAACTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT120790 WP_000587619.1 NZ_CP038183:c2503954-2503697 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT120790 NZ_CP038183:c2503954-2503697 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References